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- W2035351765 endingPage "1385" @default.
- W2035351765 startingPage "1375" @default.
- W2035351765 abstract "Effective regulation of highly compartmentalized production of reactive oxygen species and peroxidation reactions in mitochondria requires targeting of small molecule antioxidants and antioxidant enzymes into the organelles. This review describes recently developed approaches to mitochondrial targeting of small biologically active molecules based on: (i) preferential accumulation in mitochondria because of their hydrophobicity and positive charge (hydrophobic cations), (ii) binding with high affinity to an intra-mitochondrial constituent, and (iii) metabolic conversions by specific mitochondrial enzymes to reveal an active entity. In addition, targeted delivery of antioxidant enzymes via expression of leader sequences directing the proteins into mitochondria is considered. Examples of successful antioxidant and anti-apoptotic protection based on the ability of targeted cargoes to inhibit cytochrome c-catalyzed peroxidation of a mitochondria-specific phospholipid cardiolipin, in vitro and in vivo are presented. Particular emphasis is placed on the employment of triphenylphosphonium- and hemi-gramicidin S-moieties as two effective vehicles for mitochondrial delivery of antioxidants." @default.
- W2035351765 created "2016-06-24" @default.
- W2035351765 creator A5018024103 @default.
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- W2035351765 creator A5086611091 @default.
- W2035351765 date "2009-11-30" @default.
- W2035351765 modified "2023-10-16" @default.
- W2035351765 title "Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions☆" @default.
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