Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035353326> ?p ?o ?g. }
- W2035353326 abstract "It is well established that fatty acid metabolites of cyclooxygenase, lipoxygenase (LOX), and cytochrome P450 are implicated in essential aspects of cellular signaling including the induction of programmed cell death. Here we review the roles of enzymatic and nonenzymatic products of polyunsaturated fatty acids in controlling cell growth and apoptosis. Also, the spontaneous oxidation of polyunsaturated fatty acids yields reactive aldehydes and other products of lipid peroxidation that are potentially toxic to cells and may also signal apoptosis. Significant conflicting data in terms of the role of LOX enzymes are highlighted, prompting a reevaluation of the relationship between LOX and prostate cancer cell survival. We include new data showing that LNCaP, PC3, and Du145 cells express much lower levels of 5-LOX mRNA and protein compared with normal prostate epithelial cells (NHP2) and primary prostate carcinoma cells (TP1). Although the 5-LOX activating protein inhibitor MK886 killed these cells, another 5-LOX inhibitor AA861 hardly showed any effect. These observations suggest that 5-LOX is unlikely to be a prostate cancer cell survival factor, implying that the mechanisms by which LOX inhibitors induce apoptosis are more complex than expected. This review also suggests several mechanisms involving peroxisome proliferator activated receptor activation, BCL proteins, thiol regulation, and mitochondrial and kinase signaling by which cell death may be produced in response to changes in nonesterified and nonprotein bound fatty acid levels. Overall, this review provides a context within which the effects of fatty acids and fatty acid oxidation products on signal transduction pathways, particularly those involved in apoptosis, can be considered in terms of their overall importance relative to the much better studied protein or peptide signaling factors." @default.
- W2035353326 created "2016-06-24" @default.
- W2035353326 creator A5002917558 @default.
- W2035353326 creator A5041033681 @default.
- W2035353326 creator A5083404944 @default.
- W2035353326 creator A5083990383 @default.
- W2035353326 date "2002-01-12" @default.
- W2035353326 modified "2023-10-15" @default.
- W2035353326 title "Fatty Acid Oxidation and Signaling in Apoptosis" @default.
- W2035353326 cites W1479683825 @default.
- W2035353326 cites W1496561250 @default.
- W2035353326 cites W1507112934 @default.
- W2035353326 cites W1538793513 @default.
- W2035353326 cites W1552738749 @default.
- W2035353326 cites W1554143159 @default.
- W2035353326 cites W1558941327 @default.
- W2035353326 cites W1562457256 @default.
- W2035353326 cites W1563962170 @default.
- W2035353326 cites W1585216478 @default.
- W2035353326 cites W1586296071 @default.
- W2035353326 cites W1597529692 @default.
- W2035353326 cites W1600112913 @default.
- W2035353326 cites W1608005125 @default.
- W2035353326 cites W1614601899 @default.
- W2035353326 cites W161930446 @default.
- W2035353326 cites W1685518911 @default.
- W2035353326 cites W1786911182 @default.
- W2035353326 cites W1816763520 @default.
- W2035353326 cites W1856122700 @default.
- W2035353326 cites W1900846504 @default.
- W2035353326 cites W1923463372 @default.
- W2035353326 cites W1940300157 @default.
- W2035353326 cites W1942214720 @default.
- W2035353326 cites W1964617786 @default.
- W2035353326 cites W1964975312 @default.
- W2035353326 cites W1968934356 @default.
- W2035353326 cites W1970283820 @default.
- W2035353326 cites W1970866796 @default.
- W2035353326 cites W1971331737 @default.
- W2035353326 cites W1973557277 @default.
- W2035353326 cites W1973568385 @default.
- W2035353326 cites W1973942746 @default.
- W2035353326 cites W1975504666 @default.
- W2035353326 cites W1977687557 @default.
- W2035353326 cites W1978874104 @default.
- W2035353326 cites W1979003732 @default.
- W2035353326 cites W1979173881 @default.
- W2035353326 cites W1979455940 @default.
- W2035353326 cites W1980058237 @default.
- W2035353326 cites W1983577234 @default.
- W2035353326 cites W1984094934 @default.
- W2035353326 cites W1985054264 @default.
- W2035353326 cites W1985088376 @default.
- W2035353326 cites W1987088213 @default.
- W2035353326 cites W1988300812 @default.
- W2035353326 cites W1989057737 @default.
- W2035353326 cites W1989405933 @default.
- W2035353326 cites W1992377755 @default.
- W2035353326 cites W1992802454 @default.
- W2035353326 cites W1994168498 @default.
- W2035353326 cites W1994318934 @default.
- W2035353326 cites W1995495200 @default.
- W2035353326 cites W1997208169 @default.
- W2035353326 cites W1997918326 @default.
- W2035353326 cites W1997957289 @default.
- W2035353326 cites W1999368137 @default.
- W2035353326 cites W1999705714 @default.
- W2035353326 cites W2000912603 @default.
- W2035353326 cites W2002503549 @default.
- W2035353326 cites W2003537519 @default.
- W2035353326 cites W2005480061 @default.
- W2035353326 cites W2007635795 @default.
- W2035353326 cites W2007683534 @default.
- W2035353326 cites W2007861801 @default.
- W2035353326 cites W2008574812 @default.
- W2035353326 cites W2009946807 @default.
- W2035353326 cites W2010101508 @default.
- W2035353326 cites W2010135385 @default.
- W2035353326 cites W2010274910 @default.
- W2035353326 cites W2010703328 @default.
- W2035353326 cites W2013581100 @default.
- W2035353326 cites W2013862513 @default.
- W2035353326 cites W2014697941 @default.
- W2035353326 cites W2014865113 @default.
- W2035353326 cites W2016093245 @default.
- W2035353326 cites W2022677287 @default.
- W2035353326 cites W2027045857 @default.
- W2035353326 cites W2031694725 @default.
- W2035353326 cites W2033242554 @default.
- W2035353326 cites W2033417923 @default.
- W2035353326 cites W2034542419 @default.
- W2035353326 cites W2035222065 @default.
- W2035353326 cites W2035393250 @default.
- W2035353326 cites W2036599441 @default.
- W2035353326 cites W2036717856 @default.
- W2035353326 cites W2037741399 @default.
- W2035353326 cites W2038750138 @default.
- W2035353326 cites W2040849712 @default.
- W2035353326 cites W2042368197 @default.
- W2035353326 cites W2043972213 @default.