FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035355576> ?p ?o ?g. }

• W2035355576 endingPage "147" @default.
• W2035355576 startingPage "143" @default.
• W2035355576 abstract "After the introduction of valproate in 1973, excluding benzodiazepines, there was a 19 year gap before the introduction of vigabatrin, the first in a series of new antiepileptic drugs to be developed and licensed. At the time of writing gabapentin, lamotrigine, oxcarbazepine, tiagabine, and topiramate have a licence in the United Kingdom. Zonisamide and levetiracetam are licensed in some countries outside the United Kingdom. In this article, we review some of the evidence for the effectiveness and tolerability of these new drugs. We also attempt to draw attention to lessons learned and the conflict between the needs of the pharmaceutical industry, the clinician, and the patient.### DRUG REFRACTORY LOCALISATION RELATED EPILEPSYNew antiepileptic drugs are licensed as add-on treatments in the first instance, efficacy and safety having been demonstrated in randomised placebo controlled add-on trials, with additional safety data predominantly derived from follow on studies. Results from follow on studies are often difficult to interpret because comparisons are no longer randomised.Trials usually recruit patients with drug refractory partial seizures. Patients are first of all observed during a prerandomisation baseline period of 8–12 weeks duration. Provided they have a sufficient a number of seizures (usually four a week), they are randomised to have either active drug or placebo added to their regime, and are followed up for 12–16 weeks. Efficacy is assessed by comparing individual patient's seizure frequency during the treatment period with the baseline period. Median reduction in seizure frequency and the number of patients with a 50% or greater reduction in seizure frequency (responders) are usually reported as efficacy outcomes.The table summarises the results of intention to treat analyses from a systematic review of placebo controlled add on studies investigating gabapentin, lamotrigine, tiagabine, topiramate vigabatrin, and zonisamide in patients with drug refractory localisation related seizures,1 2 and in addition shows data …" @default.
• W2035355576 created "2016-06-24" @default.
• W2035355576 creator A5067654316 @default.
• W2035355576 date "2001-02-01" @default.
• W2035355576 modified "2023-10-03" @default.
• W2035355576 title "New drug treatments for epilepsy" @default.
• W2035355576 cites W1607190847 @default.
• W2035355576 cites W1732466172 @default.
• W2035355576 cites W1965450907 @default.
• W2035355576 cites W1966186739 @default.
• W2035355576 cites W1975482049 @default.
• W2035355576 cites W1976915948 @default.
• W2035355576 cites W1979819746 @default.
• W2035355576 cites W1982221637 @default.
• W2035355576 cites W1983021024 @default.
• W2035355576 cites W1996172988 @default.
• W2035355576 cites W2008863591 @default.
• W2035355576 cites W2010281261 @default.
• W2035355576 cites W2013225518 @default.
• W2035355576 cites W2016679698 @default.
• W2035355576 cites W2027242474 @default.
• W2035355576 cites W2039674635 @default.
• W2035355576 cites W2040597207 @default.
• W2035355576 cites W2040767892 @default.
• W2035355576 cites W2048532324 @default.
• W2035355576 cites W2069091142 @default.
• W2035355576 cites W2070403944 @default.
• W2035355576 cites W2072923583 @default.
• W2035355576 cites W2085059524 @default.
• W2035355576 cites W2087388267 @default.
• W2035355576 cites W2095185628 @default.
• W2035355576 cites W2098517987 @default.
• W2035355576 cites W2123287446 @default.
• W2035355576 cites W2132785864 @default.
• W2035355576 cites W2136713403 @default.
• W2035355576 cites W2139617051 @default.
• W2035355576 cites W2157944766 @default.
• W2035355576 cites W2162594619 @default.
• W2035355576 cites W2321582280 @default.
• W2035355576 cites W2614859754 @default.
• W2035355576 cites W267499062 @default.
• W2035355576 cites W641823132 @default.
• W2035355576 cites W2004801985 @default.
• W2035355576 doi "https://doi.org/10.1136/jnnp.70.2.143" @default.
• W2035355576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1737219" @default.
• W2035355576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11160458" @default.
• W2035355576 hasPublicationYear "2001" @default.
• W2035355576 type Work @default.
• W2035355576 sameAs 2035355576 @default.
• W2035355576 citedByCount "26" @default.
• W2035355576 countsByYear W20353555762013 @default.
• W2035355576 countsByYear W20353555762022 @default.
• W2035355576 crossrefType "journal-article" @default.
• W2035355576 hasAuthorship W2035355576A5067654316 @default.
• W2035355576 hasBestOaLocation W20353555761 @default.
• W2035355576 hasConcept C118552586 @default.
• W2035355576 hasConcept C2778186239 @default.
• W2035355576 hasConcept C2780035454 @default.
• W2035355576 hasConcept C71924100 @default.
• W2035355576 hasConcept C98274493 @default.
• W2035355576 hasConceptScore W2035355576C118552586 @default.
• W2035355576 hasConceptScore W2035355576C2778186239 @default.
• W2035355576 hasConceptScore W2035355576C2780035454 @default.
• W2035355576 hasConceptScore W2035355576C71924100 @default.
• W2035355576 hasConceptScore W2035355576C98274493 @default.
• W2035355576 hasIssue "2" @default.
• W2035355576 hasLocation W20353555761 @default.
• W2035355576 hasLocation W20353555762 @default.
• W2035355576 hasLocation W20353555763 @default.
• W2035355576 hasLocation W20353555764 @default.
• W2035355576 hasOpenAccess W2035355576 @default.
• W2035355576 hasPrimaryLocation W20353555761 @default.
• W2035355576 hasRelatedWork W1506200166 @default.
• W2035355576 hasRelatedWork W1995515455 @default.
• W2035355576 hasRelatedWork W2048182022 @default.
• W2035355576 hasRelatedWork W2080531066 @default.
• W2035355576 hasRelatedWork W2604872355 @default.
• W2035355576 hasRelatedWork W2748952813 @default.
• W2035355576 hasRelatedWork W2899084033 @default.
• W2035355576 hasRelatedWork W3031052312 @default.
• W2035355576 hasRelatedWork W3032375762 @default.
• W2035355576 hasRelatedWork W3108674512 @default.
• W2035355576 hasVolume "70" @default.
• W2035355576 isParatext "false" @default.
• W2035355576 isRetracted "false" @default.
• W2035355576 magId "2035355576" @default.
• W2035355576 workType "article" @default.