Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035362975> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2035362975 endingPage "92" @default.
- W2035362975 startingPage "85" @default.
- W2035362975 abstract "Bioassays for human erythropoietin are cumbersome, time-consuming, and insensitive. The purification of human erythropoietin (EP) had provided small quantities of highly bioactive EP (approximately 70,000 U/mg) required for the development of an EP radioimmunoassay (RIA). The RIA for EP described in this investigation, can detect 5 mU/ml of EP in the assay tube; the serum concentration of EP in normal individuals ranged from less than 18 to 81 mU/ml with a mean value of 29 mU/ml. In contrast, nine patients with severe aplastic anemia had markedly elevated serum EP concentrations with a mean value of 3,487 mU/ml, range 984--6,434 mU/ml. In this RIA, patients with Polycythemia vera had consistently undetectable EP concentrations, less than 18 mU/ml. Eleven patients with chronic renal failure had a higher mean serum EP concentration (40.5 mU/ml) than normal individuals, but the range (less than 18-115 mU/ml) overlapped that of normals. By immunologic and gel chromatographic criteria, EP measured in serum was similar to standard urinary EP. The EP immunoassay that we have developed has sufficient sensitivity and specificity not only to quantitate the elevated serum EP levels found in aplastic anemia but also to discriminate decreased from normal serum concentrations of EP in most circumstances. This simple, reliable RIA has provided the necessary framework upon which to increase our understanding of the importance of EP in hematopoiesis." @default.
- W2035362975 created "2016-06-24" @default.
- W2035362975 creator A5014757102 @default.
- W2035362975 creator A5054187507 @default.
- W2035362975 creator A5072320359 @default.
- W2035362975 date "1981-08-01" @default.
- W2035362975 modified "2023-10-15" @default.
- W2035362975 title "Serum concentrations of erythropoietin measured by radioimmunoassay in hematologic disorders and chronic renal failure" @default.
- W2035362975 cites W1012979883 @default.
- W2035362975 cites W1541049769 @default.
- W2035362975 cites W1955991149 @default.
- W2035362975 cites W1963782914 @default.
- W2035362975 cites W1991068695 @default.
- W2035362975 cites W1994005628 @default.
- W2035362975 cites W2002712648 @default.
- W2035362975 cites W2034523390 @default.
- W2035362975 cites W2041691113 @default.
- W2035362975 cites W2077147171 @default.
- W2035362975 cites W2080580789 @default.
- W2035362975 cites W2101787848 @default.
- W2035362975 cites W2112375936 @default.
- W2035362975 cites W2170150610 @default.
- W2035362975 cites W2282290234 @default.
- W2035362975 cites W2321438092 @default.
- W2035362975 cites W2321471620 @default.
- W2035362975 cites W2330172985 @default.
- W2035362975 cites W2413952635 @default.
- W2035362975 cites W4241522512 @default.
- W2035362975 doi "https://doi.org/10.1002/ajh.2830110110" @default.
- W2035362975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7270548" @default.
- W2035362975 hasPublicationYear "1981" @default.
- W2035362975 type Work @default.
- W2035362975 sameAs 2035362975 @default.
- W2035362975 citedByCount "51" @default.
- W2035362975 countsByYear W20353629752012 @default.
- W2035362975 crossrefType "journal-article" @default.
- W2035362975 hasAuthorship W2035362975A5014757102 @default.
- W2035362975 hasAuthorship W2035362975A5054187507 @default.
- W2035362975 hasAuthorship W2035362975A5072320359 @default.
- W2035362975 hasConcept C109159458 @default.
- W2035362975 hasConcept C126322002 @default.
- W2035362975 hasConcept C134018914 @default.
- W2035362975 hasConcept C159654299 @default.
- W2035362975 hasConcept C176685330 @default.
- W2035362975 hasConcept C185592680 @default.
- W2035362975 hasConcept C203014093 @default.
- W2035362975 hasConcept C2778248108 @default.
- W2035362975 hasConcept C2778534260 @default.
- W2035362975 hasConcept C2778837598 @default.
- W2035362975 hasConcept C2779703530 @default.
- W2035362975 hasConcept C2780007613 @default.
- W2035362975 hasConcept C2780420688 @default.
- W2035362975 hasConcept C2781440808 @default.
- W2035362975 hasConcept C28328180 @default.
- W2035362975 hasConcept C2993356106 @default.
- W2035362975 hasConcept C54355233 @default.
- W2035362975 hasConcept C71924100 @default.
- W2035362975 hasConcept C86803240 @default.
- W2035362975 hasConceptScore W2035362975C109159458 @default.
- W2035362975 hasConceptScore W2035362975C126322002 @default.
- W2035362975 hasConceptScore W2035362975C134018914 @default.
- W2035362975 hasConceptScore W2035362975C159654299 @default.
- W2035362975 hasConceptScore W2035362975C176685330 @default.
- W2035362975 hasConceptScore W2035362975C185592680 @default.
- W2035362975 hasConceptScore W2035362975C203014093 @default.
- W2035362975 hasConceptScore W2035362975C2778248108 @default.
- W2035362975 hasConceptScore W2035362975C2778534260 @default.
- W2035362975 hasConceptScore W2035362975C2778837598 @default.
- W2035362975 hasConceptScore W2035362975C2779703530 @default.
- W2035362975 hasConceptScore W2035362975C2780007613 @default.
- W2035362975 hasConceptScore W2035362975C2780420688 @default.
- W2035362975 hasConceptScore W2035362975C2781440808 @default.
- W2035362975 hasConceptScore W2035362975C28328180 @default.
- W2035362975 hasConceptScore W2035362975C2993356106 @default.
- W2035362975 hasConceptScore W2035362975C54355233 @default.
- W2035362975 hasConceptScore W2035362975C71924100 @default.
- W2035362975 hasConceptScore W2035362975C86803240 @default.
- W2035362975 hasIssue "1" @default.
- W2035362975 hasLocation W20353629751 @default.
- W2035362975 hasLocation W20353629752 @default.
- W2035362975 hasOpenAccess W2035362975 @default.
- W2035362975 hasPrimaryLocation W20353629751 @default.
- W2035362975 hasRelatedWork W1547039044 @default.
- W2035362975 hasRelatedWork W2005686833 @default.
- W2035362975 hasRelatedWork W2012282646 @default.
- W2035362975 hasRelatedWork W2040842109 @default.
- W2035362975 hasRelatedWork W2046554908 @default.
- W2035362975 hasRelatedWork W2079650082 @default.
- W2035362975 hasRelatedWork W2100511451 @default.
- W2035362975 hasRelatedWork W2329075819 @default.
- W2035362975 hasRelatedWork W2416599184 @default.
- W2035362975 hasRelatedWork W4301968259 @default.
- W2035362975 hasVolume "11" @default.
- W2035362975 isParatext "false" @default.
- W2035362975 isRetracted "false" @default.
- W2035362975 magId "2035362975" @default.
- W2035362975 workType "article" @default.