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- W2035368381 abstract "A subpopulation of scleroderma dermal fibroblasts was identified by flow cytometric analysis. Between 15% and 25% of the cells within the scleroderma fibroblast lines had high levels of cytoplasmic granularity, as identified by side light scatter characteristics. Similar fibroblasts composed less than 3% of the cells within the normal fibroblast lines, although greater numbers could be induced through exposure to soluble factors derived from activated mononuclear cells. The granular subpopulation of fibroblasts produced 2-3 times as much procollagen as did the other fibroblasts. These data support the hypothesis that fibrosis in scleroderma may result in part from the activity of an inherently high procollagen-producing subset of normal fibroblasts that is expanded through exposure to immune cytokines." @default.
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- W2035368381 date "1990-06-01" @default.
- W2035368381 modified "2023-09-27" @default.
- W2035368381 title "In vitro identification of a subpopulation of fibroblasts that produces high levels of collagen in scleroderma patients" @default.
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- W2035368381 doi "https://doi.org/10.1002/art.1780330611" @default.
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