Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035369578> ?p ?o ?g. }
- W2035369578 endingPage "8" @default.
- W2035369578 startingPage "1" @default.
- W2035369578 abstract "Yokukansan, one of the traditional Japanese herbal medicines, ameliorated neuropathic pain symptoms in patients. In this study, we investigated the effects of yokukansan on neuropathic pain in chronic constriction injury (CCI) model. Oral administration of yokukansan significantly inhibited mechanical and cold allodynia in the von Frey hair or acetone test, respectively. In comparison, amitriptyline, a tricyclic antidepressant, demonstrated moderate, but not significant, antiallodynic effects in the mechanical and cold tests. Yokukansan significantly inhibited the cerebrospinal fluid dialysate level of glutamate that had increased by the stimulation of brush or acetone. Glutamate transporter inhibitors, DL-threo-beta-hydroxy aspartate and dihydrokainate, decreased the yokukansan-induced antiallodynic actions in CCI rats. Our results suggest that yokukansan was confirmed to have antiallodynic effects in CCI rats, which are related to a blockade of glutamatergic neurotransmission via activation of glutamate transporters in the spinal cord." @default.
- W2035369578 created "2016-06-24" @default.
- W2035369578 creator A5058341881 @default.
- W2035369578 creator A5083761766 @default.
- W2035369578 creator A5088498380 @default.
- W2035369578 creator A5088840185 @default.
- W2035369578 date "2012-01-01" @default.
- W2035369578 modified "2023-10-17" @default.
- W2035369578 title "Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction Injury" @default.
- W2035369578 cites W1558688164 @default.
- W2035369578 cites W1963844198 @default.
- W2035369578 cites W1969040411 @default.
- W2035369578 cites W1974886457 @default.
- W2035369578 cites W1977505230 @default.
- W2035369578 cites W1980016883 @default.
- W2035369578 cites W1984609948 @default.
- W2035369578 cites W1991624828 @default.
- W2035369578 cites W2004335391 @default.
- W2035369578 cites W2007063636 @default.
- W2035369578 cites W2010214139 @default.
- W2035369578 cites W2012398804 @default.
- W2035369578 cites W2012520893 @default.
- W2035369578 cites W2029831678 @default.
- W2035369578 cites W2039519643 @default.
- W2035369578 cites W2057982488 @default.
- W2035369578 cites W2058020736 @default.
- W2035369578 cites W2060316458 @default.
- W2035369578 cites W2080660887 @default.
- W2035369578 cites W2087253553 @default.
- W2035369578 cites W2087541289 @default.
- W2035369578 cites W2102023851 @default.
- W2035369578 cites W2121270079 @default.
- W2035369578 cites W2128412489 @default.
- W2035369578 cites W2136883509 @default.
- W2035369578 cites W2145983425 @default.
- W2035369578 cites W2154320128 @default.
- W2035369578 cites W2162026041 @default.
- W2035369578 cites W4243183567 @default.
- W2035369578 cites W4323966264 @default.
- W2035369578 doi "https://doi.org/10.1155/2012/953459" @default.
- W2035369578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3292174" @default.
- W2035369578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22454692" @default.
- W2035369578 hasPublicationYear "2012" @default.
- W2035369578 type Work @default.
- W2035369578 sameAs 2035369578 @default.
- W2035369578 citedByCount "34" @default.
- W2035369578 countsByYear W20353695782012 @default.
- W2035369578 countsByYear W20353695782013 @default.
- W2035369578 countsByYear W20353695782014 @default.
- W2035369578 countsByYear W20353695782015 @default.
- W2035369578 countsByYear W20353695782016 @default.
- W2035369578 countsByYear W20353695782017 @default.
- W2035369578 countsByYear W20353695782018 @default.
- W2035369578 countsByYear W20353695782020 @default.
- W2035369578 countsByYear W20353695782021 @default.
- W2035369578 countsByYear W20353695782022 @default.
- W2035369578 countsByYear W20353695782023 @default.
- W2035369578 crossrefType "journal-article" @default.
- W2035369578 hasAuthorship W2035369578A5058341881 @default.
- W2035369578 hasAuthorship W2035369578A5083761766 @default.
- W2035369578 hasAuthorship W2035369578A5088498380 @default.
- W2035369578 hasAuthorship W2035369578A5088840185 @default.
- W2035369578 hasBestOaLocation W20353695781 @default.
- W2035369578 hasConcept C126322002 @default.
- W2035369578 hasConcept C170493617 @default.
- W2035369578 hasConcept C2777107010 @default.
- W2035369578 hasConcept C2780216858 @default.
- W2035369578 hasConcept C42219234 @default.
- W2035369578 hasConcept C61174792 @default.
- W2035369578 hasConcept C71924100 @default.
- W2035369578 hasConcept C98274493 @default.
- W2035369578 hasConceptScore W2035369578C126322002 @default.
- W2035369578 hasConceptScore W2035369578C170493617 @default.
- W2035369578 hasConceptScore W2035369578C2777107010 @default.
- W2035369578 hasConceptScore W2035369578C2780216858 @default.
- W2035369578 hasConceptScore W2035369578C42219234 @default.
- W2035369578 hasConceptScore W2035369578C61174792 @default.
- W2035369578 hasConceptScore W2035369578C71924100 @default.
- W2035369578 hasConceptScore W2035369578C98274493 @default.
- W2035369578 hasLocation W20353695781 @default.
- W2035369578 hasLocation W20353695782 @default.
- W2035369578 hasLocation W20353695783 @default.
- W2035369578 hasLocation W20353695784 @default.
- W2035369578 hasLocation W20353695785 @default.
- W2035369578 hasOpenAccess W2035369578 @default.
- W2035369578 hasPrimaryLocation W20353695781 @default.
- W2035369578 hasRelatedWork W2031137391 @default.
- W2035369578 hasRelatedWork W2041047580 @default.
- W2035369578 hasRelatedWork W2042001134 @default.
- W2035369578 hasRelatedWork W2065601980 @default.
- W2035369578 hasRelatedWork W2083614307 @default.
- W2035369578 hasRelatedWork W2160195671 @default.
- W2035369578 hasRelatedWork W2349577666 @default.
- W2035369578 hasRelatedWork W2380091838 @default.
- W2035369578 hasRelatedWork W2416443598 @default.
- W2035369578 hasRelatedWork W4224929841 @default.
- W2035369578 hasVolume "2012" @default.
- W2035369578 isParatext "false" @default.