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- W2035377225 abstract "The diabetic peripheral neuropathy (DPN) is the most common diabetic patients' complication which is accompanied with substantial economic burden regarding the productivity loss and medical therapy. In this study we analyzed the cost effectiveness of pregabalin for treatment of diabetic neuropathic pain in Iran. To evaluate the efficacy of pregabalin we designed a systematic review of published articles by searching on PubMed, Scopus and Google scholar. Our keywords were: “pregabalin”, “neuropathic pain”, “diabetic peripheral neuropathy”, etc. The pain score was the outcome of interest for evaluation of the treatment efficacy in peripheral neuropathic pain. For calculation of cost we only consider direct cost of treatment. Out of 8994, finally 5 articles were included in the study which met our inclusion criteria. All of these reports were Randomized Clinical Trial (RCT) of the comparison of pregabalin with placebo. Considering the efficacy extracted from the reports, pregabalin 75 mg/day and 150 mg/day didn't have any significant efficacy in comparison with placebo thus the ICER for other treatment doses was calculated. In pregabalin 300 mg/day the ICER for domestic produced generic pregabalin was 0.27 dollar per day per pain score reduction and for imported Lyrica was 2.74 dollar per day per pain score reduction. The results for pregabalin 600 mg/day were 0.62 and 4.37 respectively. Our analysis indicated pregabalin 300 mg/day and 600 mg/day as cost effective treatments. About the inclusion of pregabalin into insurance positive list if the prescribers prefer to order pregabalin once a day (As we learned from the expert opinion) therefore only 300 mg and 600 mg dosage forms are eligible for including into the positive list." @default.
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- W2035377225 date "2012-11-01" @default.
- W2035377225 modified "2023-10-05" @default.
- W2035377225 title "PDB24 Cost- Effectiveness Analysis of Pregabalin in the Treatment of Diabetic Peripheral Neuropathy" @default.
- W2035377225 doi "https://doi.org/10.1016/j.jval.2012.08.355" @default.
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