Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035378229> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2035378229 endingPage "290A" @default.
- W2035378229 startingPage "290A" @default.
- W2035378229 abstract "The systematic study of the pathogenesis of human herpesvirus has been possible using guinea pig (GP) models. GP cytomegalovirus (CMV) infection results in a limited (approx. 12 wks) productive infection; while GP herpes-like-virus (HLV), recently proposed as a model for human Epstein Bar Virus, results in prolonged indefinite productive infection. In humans, cessation of productive CMV infection has been associated with CMV-specific cell-mediated immune function (CMI). 51Cr release assays were developed for natural killer (NK) activity and memory dependent genetically restricted cellular cytotoxicity (MRCC) to HLV and CMV using a 12 hr assay and an effector:target ratio of 100:1. Animals with (+) and without (-) chronic HLV or CMV infections were studied. Six animals (HLV+/CMV-) showed minimal NK activity (40%) or MRCC (4%) against HLV infected targets, however, NK activity (20%) was present for CMV targets. Three animals (HLV-/CMV+) showed NK activity (9%) but no MRCC (≤3%) against HLV targets as well as NK activity (26%) and MRCC (9%) to CMV targets. Three animals (HLV-/CMV-) showed NK activity and no MRCC to HLV (9% and ≤13%) or CMV (19% and ≤ 3%) targets. Two animals (HLV+/CMV+) exhibited both NK activity and MRCC to HLV (7% and 7%) and CMV (39% and 8%) targets. HLV is not globally immunosuppressive since CM V specific NK activity and MRCC are present in HLV+/CMV+ animals. Preliminary data suggest that chronic productive HLV infection may be due to insufficient HLV specific cytotoxic CMI (NK activity or MRCC)." @default.
- W2035378229 created "2016-06-24" @default.
- W2035378229 creator A5035598656 @default.
- W2035378229 creator A5046327124 @default.
- W2035378229 date "1985-04-01" @default.
- W2035378229 modified "2023-10-18" @default.
- W2035378229 title "1079 CHRONIC PRODUCTIVE HERPESVIRUS INFECTION IS ASSOCIATED WITH INSUFFICIENT VIRUS-SPECIFIC CYTOTOXIC CELL-MEDIATED IMMUNE RESPONSE" @default.
- W2035378229 doi "https://doi.org/10.1203/00006450-198504000-01109" @default.
- W2035378229 hasPublicationYear "1985" @default.
- W2035378229 type Work @default.
- W2035378229 sameAs 2035378229 @default.
- W2035378229 citedByCount "0" @default.
- W2035378229 crossrefType "journal-article" @default.
- W2035378229 hasAuthorship W2035378229A5035598656 @default.
- W2035378229 hasAuthorship W2035378229A5046327124 @default.
- W2035378229 hasBestOaLocation W20353782291 @default.
- W2035378229 hasConcept C154317977 @default.
- W2035378229 hasConcept C159047783 @default.
- W2035378229 hasConcept C202751555 @default.
- W2035378229 hasConcept C203014093 @default.
- W2035378229 hasConcept C2522874641 @default.
- W2035378229 hasConcept C2776409557 @default.
- W2035378229 hasConcept C2777662283 @default.
- W2035378229 hasConcept C2777732132 @default.
- W2035378229 hasConcept C2779820661 @default.
- W2035378229 hasConcept C2780727368 @default.
- W2035378229 hasConcept C55493867 @default.
- W2035378229 hasConcept C86803240 @default.
- W2035378229 hasConcept C8891405 @default.
- W2035378229 hasConceptScore W2035378229C154317977 @default.
- W2035378229 hasConceptScore W2035378229C159047783 @default.
- W2035378229 hasConceptScore W2035378229C202751555 @default.
- W2035378229 hasConceptScore W2035378229C203014093 @default.
- W2035378229 hasConceptScore W2035378229C2522874641 @default.
- W2035378229 hasConceptScore W2035378229C2776409557 @default.
- W2035378229 hasConceptScore W2035378229C2777662283 @default.
- W2035378229 hasConceptScore W2035378229C2777732132 @default.
- W2035378229 hasConceptScore W2035378229C2779820661 @default.
- W2035378229 hasConceptScore W2035378229C2780727368 @default.
- W2035378229 hasConceptScore W2035378229C55493867 @default.
- W2035378229 hasConceptScore W2035378229C86803240 @default.
- W2035378229 hasConceptScore W2035378229C8891405 @default.
- W2035378229 hasIssue "4" @default.
- W2035378229 hasLocation W20353782291 @default.
- W2035378229 hasOpenAccess W2035378229 @default.
- W2035378229 hasPrimaryLocation W20353782291 @default.
- W2035378229 hasRelatedWork W1984465656 @default.
- W2035378229 hasRelatedWork W1997042350 @default.
- W2035378229 hasRelatedWork W2075557935 @default.
- W2035378229 hasRelatedWork W2103554102 @default.
- W2035378229 hasRelatedWork W2113217993 @default.
- W2035378229 hasRelatedWork W2415069152 @default.
- W2035378229 hasRelatedWork W4235529908 @default.
- W2035378229 hasRelatedWork W4245101942 @default.
- W2035378229 hasRelatedWork W4249253247 @default.
- W2035378229 hasRelatedWork W4251573553 @default.
- W2035378229 hasVolume "19" @default.
- W2035378229 isParatext "false" @default.
- W2035378229 isRetracted "false" @default.
- W2035378229 magId "2035378229" @default.
- W2035378229 workType "article" @default.