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- W2035392212 abstract "Human immunodeficiency virus (HIV) infection is associated with many malignancies, including lymphoma, Kaposi’s sarcoma and smooth muscle tumors such as leiomyosarcoma and leiomyoma. An association between the Epstein-Bm virus and smooth muscle tumors in immunmmpromised patients has been reported previously in the liver. lung, adrenal gland and gastrointestinal tract. In situ hybridization, polymerase chain reaction and immunostaining have demonstrated Epstein-Bm virus infection of smooth muscle tumor cells in immunocompromised patients.’ To our knowledge we report on the first adult positive for HIV to have Epstein-Barr virus induced renal leiomyoma. CASE REPORT A 37-year-old white man with an 8-year history of HIV presented with fever of unknown origin. Abdominal computerized tomography tCT) revealed a 2 X 3 cm. left renal mass (fig. 1). Repeat scan at 3 months suggested interval growth. Metastatic evaluation by CT, chest x-ray and laboratory analysis was negative. The patient underwent left radical nephrectomy. Convalescence was unremarkable. Pathological examination of the kidney revealed a 3.0 X 2.8 x 2.5 cm. well circumscribed renal leiomyoma (fig. 2). In situ hybridization and immunostaining confirmed EpsteinBarr virus infection of the smooth muscle tumor cells. DISCUSSION The Epstein-Barr virus is a member of the human herpes virus family. Primary infection with this virus manifests as mild self-limited illness to infectious mononucleosis. Disease begins in the oropharyngeal epithelial cells. The Epstein-Barr virus then infects B lymphocytes, which harbor latent virus and are important in the dissemination of the virus to other tissues. A broad immune response to the Epstein-Barr virus controls proliferation.2 In immunocompromised patients this response is suppressed, allowing uncontrolled viral proliferation." @default.
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- W2035392212 date "1999-01-01" @default.
- W2035392212 modified "2023-09-29" @default.
- W2035392212 title "EPSTEIN-BARR VIRUS INDUCED RENAL LEIOMYOMA" @default.
- W2035392212 cites W1598586133 @default.
- W2035392212 cites W1969743670 @default.
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- W2035392212 doi "https://doi.org/10.1016/s0022-5347(01)62101-3" @default.
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