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• W2035394030 abstract "Objectives Inherited and acquired risk factors contribute to the development of the atherosclerotic lesion and its most common clinical manifestation, myocardial infarction (MI). Multiple studies have suggested a role for matrix metalloproteinases (MMPs) in atherosclerosis, and several functional polymorphisms in the MMP-1 gene have been linked to the risk of MI. The aim of this study was to evaluate the association between MMP-1 promoter polymorphisms and early MI in a Spanish cohort. Methods We carried out a case–control study with 261 unrelated patients who had suffered an MI before 55 years of age and 194 healthy controls, all male and smokers. The genotypes for the three MMP-1 promoter polymorphisms −1607 1G/2G, −519 A/G, and −340 T/C were determined through PCR–restriction fragment length polymorphism. Allelic, genotypic, and haplotypic frequencies were statistically compared between groups. Results Frequencies of the three polymorphisms did not differ between patients and controls. The −1607 1G/2G and −519 A/G variants were in linkage disequilibrium. Analysis of the haplotype frequencies showed significant associations of the 2G−1607-G−519-T−340 (odds ratio = 2.40; 95% confidence interval = 1.27–4.55; P<0.006) and 1G−1607-G−519-T−340 (odds ratio = 0.68; 95% confidence interval = 0.50–0.94; P<0.05) haplotypes with the risk of early MI. Conclusion MMP-1 promoter polymorphisms are associated with the risk of early MI in a Spanish population of smoking males." @default.
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• W2035394030 date "2009-09-01" @default.
• W2035394030 modified "2023-10-18" @default.
• W2035394030 title "Matrix metalloproteinase 1 promoter polymorphisms and risk of myocardial infarction: a case–control study in a Spanish population" @default.
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• W2035394030 doi "https://doi.org/10.1097/mca.0b013e32832fa9cf" @default.
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