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- W2035401282 abstract "Sheep were experimentally infected orally with Mycobacterium johnei and their immune response assessed by measurement of delayed-type skin hypersensitivity, viable unit counts of M. johnei in the tissues, and by pathology, histochemistry and serial biopsies of selected sheep. In those killed shortly after infection, the rapid development of a “strong” degree of skin hypersensitivity was associated with low levels of intestinal infection. However, the failure to mount a “strong” degree of skin hypersensitivity did not preclude eventual recovery from the infection. Electron microscopy of macrophages within lesions in sheep with “strong” skin hypersensitivity showed mainly degenerating bacilli, in contrast to those from sheep with “weak” skin hypersensitivity where the macrophages in similar lesions often contained numerous intact bacilli. The finding of cells rich in β-galactosidase in the lesions bore no relationship to the extent of infection." @default.
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- W2035401282 date "1977-10-01" @default.
- W2035401282 modified "2023-09-30" @default.
- W2035401282 title "Intestinal infection and host response to oral administration of Mycobacterium johnei in sheep" @default.
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- W2035401282 doi "https://doi.org/10.1016/0378-1135(77)90015-3" @default.
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