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- W2035410588 abstract "A 25-year-old woman presented with complaints of dark discolouration of the hands, feet and the tip of the nose 1 week after normal delivery of a preterm baby (28 weeks) in April 2009. The onset was subacute and the discolouration progressed to the wrists and just above the ankles in a bilaterally symmetrical fashion. There was a history of fever from the onset of symptoms. There was no prior history of diabetes or cardiovascular illness. The baby had to be kept in the neonatal intensive care unit for 2 weeks hospitalization, as he was premature, and suffering from acute respiratory distress. On examination, the vital signs were: pulse 94 beats per minute and blood pressure of 118/72 mm/Hg, respirations 18 breaths/min. She had superficial pregangrene of the tip of the nose (Fig. 1), hands and feet extending to the distal leg. Superficial ulcerations were absent (Fig. 2). The skin of pregangrenous area was dry. The patient could move her hands and feet, but there was partial loss of sensation in the area of superficial pregangrene. She had moderate pallor, but no cyanosis. Examinations of the chest and abdomen were normal. The hemoglobin was 9.5 gm%, blood urea 22 mg% and serum creatinine 1 mg%. Her platelet count, prothrombin time and activated partial thromboplastin time were normal. A blood culture was negative. The anticardiolipin antibody (aCL) test was positive however a Lupus anticoagulant (LCA) test was not done. Protein C, protein S and antithrombin III levels were normal. Antinuclear antibody test and antibodies to double stranded DNA (ds-DNA) for systemic lupus erythematosus were negative. The chest X-ray study as well as a urinalysis was normal. The ultrasonography of the pelvis showed a mildly enlarged uterus without any fluid collection in the pelvis. The aCL test was still positive after 6 weeks." @default.
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- W2035410588 date "2011-11-01" @default.
- W2035410588 modified "2023-09-24" @default.
- W2035410588 title "Symmetrical peripheral gangrene: a rare presentation of antiphospholipid syndrome" @default.
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- W2035410588 doi "https://doi.org/10.1007/s11739-011-0714-4" @default.
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