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• W2035442968 startingPage "7513" @default.
• W2035442968 abstract "ABSTRACT As one of the world's most common infectious diseases, hepatitis B virus (HBV) is a serious worldwide public health problem, with HBV-associated liver disease accounting for more than half a million deaths each year. Although there is an effective prophylactic vaccine currently available to prevent infection, it has a number of characteristics that are suboptimal: multiple doses are needed to induce long-lasting immunity, immunity declines over time, it does not elicit protection in some individuals, and it is not effective therapeutically. We produced a recombinant vesicular stomatitis virus (VSV)-based vaccine vector expressing the HBV middle envelope surface protein (MS) and found that this vector was able to efficiently generate a strong HBs-specific antibody response following a single immunization in mice. A single immunization with the VSV-MS vector also induced robust CD8 T-cell activation. The CD8 T-cell response was greater in magnitude and broader in specificity than the response generated by a vaccinia virus-based vaccine vector or by recombinant protein immunization. Furthermore, a single VSV-MS immunization provided protection against virus challenge in mice. Given the similar antibody titers and superior T-cell responses elicited from a single immunization, a VSV-based HBV vaccine may have advantages over the current recombinant protein vaccine." @default.
• W2035442968 created "2016-06-24" @default.
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• W2035442968 date "2010-08-01" @default.
• W2035442968 modified "2023-10-11" @default.
• W2035442968 title "A Vesicular Stomatitis Virus-Based Hepatitis B Virus Vaccine Vector Provides Protection against Challenge in a Single Dose" @default.
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• W2035442968 doi "https://doi.org/10.1128/jvi.00200-10" @default.
• W2035442968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2897621" @default.
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• W2035442968 hasPublicationYear "2010" @default.
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