FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035443352> ?p ?o ?g. }

• W2035443352 abstract "New Zealand White rabbits were treated orally with 0 (controls), 50, 100, or 150 mg/kg phenytoin on days 14-16 of pregnancy. Total and free plasma concentrations of phenytoin were determined in maternal plasma 2, 6, and 24 hr after the final dose in all animals. In addition, after administration of 150 mg/kg maternal plasma concentrations were also determined after 12 and 48 hr, the concentrations in amniotic fluid after 6 hr, and those in fetal tissue 6 and 24 hr after the final treatment. A high degree of plasma protein binding was observed in maternal blood. Treatment with 50 mg/kg resulted in free plasma concentrations of up to 5.0 mumol/l during the 24 hr period following the final dose. Significantly higher free plasma concentrations were observed at the two higher dose levels; up to 9.7 mumol/l at 100 mg/kg and 12.7 mumol/l at 150 mg/kg. Digital hypoplasia was not seen in the control group or the animals treated with 50 mg/kg. However, treatment with 100 mg/kg resulted in hypoplasia in a single or a few digits in approximately 50% of the fetuses, and 150 mg/kg provoked hypoplasia in almost all digits in all fetuses. These results show that even though the doses which caused digital defects in rabbits are much higher than those used therapeutically, the resulting free concentrations of phenytoin are similar to those which are associated with the same type of defects in humans. These data indicate that the pharmacologically induced fetal hypoxia/ischemia and vascular disruption preceding malformations of this type, which were observed in a previous study in rabbits, may be of human relevance." @default.
• W2035443352 created "2016-06-24" @default.
• W2035443352 creator A5019416797 @default.
• W2035443352 creator A5081928550 @default.
• W2035443352 creator A5083549274 @default.
• W2035443352 date "1995-11-01" @default.
• W2035443352 modified "2023-10-12" @default.
• W2035443352 title "Phenytoin causes phalangeal hypoplasia in the rabbit fetus at clinically relevant free plasma concentrations" @default.
• W2035443352 cites W1548208927 @default.
• W2035443352 cites W1963868089 @default.
• W2035443352 cites W1965016127 @default.
• W2035443352 cites W1966350344 @default.
• W2035443352 cites W1977021728 @default.
• W2035443352 cites W1977721529 @default.
• W2035443352 cites W1992458790 @default.
• W2035443352 cites W1996558914 @default.
• W2035443352 cites W1999583795 @default.
• W2035443352 cites W2002688001 @default.
• W2035443352 cites W2005694851 @default.
• W2035443352 cites W2007583911 @default.
• W2035443352 cites W2012908486 @default.
• W2035443352 cites W2025421356 @default.
• W2035443352 cites W2026656372 @default.
• W2035443352 cites W2046599611 @default.
• W2035443352 cites W2050526537 @default.
• W2035443352 cites W2051047506 @default.
• W2035443352 cites W2056371102 @default.
• W2035443352 cites W2059940903 @default.
• W2035443352 cites W2064047647 @default.
• W2035443352 cites W2069065045 @default.
• W2035443352 cites W2082570078 @default.
• W2035443352 cites W2085299245 @default.
• W2035443352 cites W2088129118 @default.
• W2035443352 cites W2089463259 @default.
• W2035443352 cites W2098095640 @default.
• W2035443352 cites W2098699260 @default.
• W2035443352 cites W2197227471 @default.
• W2035443352 cites W2202238338 @default.
• W2035443352 cites W4211161723 @default.
• W2035443352 doi "https://doi.org/10.1002/tera.1420520503" @default.
• W2035443352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8838248" @default.
• W2035443352 hasPublicationYear "1995" @default.
• W2035443352 type Work @default.
• W2035443352 sameAs 2035443352 @default.
• W2035443352 citedByCount "22" @default.
• W2035443352 countsByYear W20354433522012 @default.
• W2035443352 countsByYear W20354433522019 @default.
• W2035443352 crossrefType "journal-article" @default.
• W2035443352 hasAuthorship W2035443352A5019416797 @default.
• W2035443352 hasAuthorship W2035443352A5081928550 @default.
• W2035443352 hasAuthorship W2035443352A5083549274 @default.
• W2035443352 hasConcept C118552586 @default.
• W2035443352 hasConcept C126322002 @default.
• W2035443352 hasConcept C134018914 @default.
• W2035443352 hasConcept C172680121 @default.
• W2035443352 hasConcept C185592680 @default.
• W2035443352 hasConcept C2776575606 @default.
• W2035443352 hasConcept C2778186239 @default.
• W2035443352 hasConcept C2778194526 @default.
• W2035443352 hasConcept C2778337148 @default.
• W2035443352 hasConcept C2779234561 @default.
• W2035443352 hasConcept C2780327212 @default.
• W2035443352 hasConcept C54355233 @default.
• W2035443352 hasConcept C65290608 @default.
• W2035443352 hasConcept C71924100 @default.
• W2035443352 hasConcept C86803240 @default.
• W2035443352 hasConceptScore W2035443352C118552586 @default.
• W2035443352 hasConceptScore W2035443352C126322002 @default.
• W2035443352 hasConceptScore W2035443352C134018914 @default.
• W2035443352 hasConceptScore W2035443352C172680121 @default.
• W2035443352 hasConceptScore W2035443352C185592680 @default.
• W2035443352 hasConceptScore W2035443352C2776575606 @default.
• W2035443352 hasConceptScore W2035443352C2778186239 @default.
• W2035443352 hasConceptScore W2035443352C2778194526 @default.
• W2035443352 hasConceptScore W2035443352C2778337148 @default.
• W2035443352 hasConceptScore W2035443352C2779234561 @default.
• W2035443352 hasConceptScore W2035443352C2780327212 @default.
• W2035443352 hasConceptScore W2035443352C54355233 @default.
• W2035443352 hasConceptScore W2035443352C65290608 @default.
• W2035443352 hasConceptScore W2035443352C71924100 @default.
• W2035443352 hasConceptScore W2035443352C86803240 @default.
• W2035443352 hasLocation W20354433521 @default.
• W2035443352 hasLocation W20354433522 @default.
• W2035443352 hasOpenAccess W2035443352 @default.
• W2035443352 hasPrimaryLocation W20354433521 @default.
• W2035443352 hasRelatedWork W2012168761 @default.
• W2035443352 hasRelatedWork W2018613613 @default.
• W2035443352 hasRelatedWork W2022187101 @default.
• W2035443352 hasRelatedWork W2039615008 @default.
• W2035443352 hasRelatedWork W2076756818 @default.
• W2035443352 hasRelatedWork W2091151050 @default.
• W2035443352 hasRelatedWork W2095329316 @default.
• W2035443352 hasRelatedWork W2128336128 @default.
• W2035443352 hasRelatedWork W2131811784 @default.
• W2035443352 hasRelatedWork W2141521254 @default.
• W2035443352 isParatext "false" @default.
• W2035443352 isRetracted "false" @default.
• W2035443352 magId "2035443352" @default.
• W2035443352 workType "article" @default.