Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035449853> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2035449853 endingPage "40" @default.
- W2035449853 startingPage "37" @default.
- W2035449853 abstract "The mechanism whereby hyperglycaemia inhibits neutrophil function is unclear. We have examined neutrophil killing of Candida albicans in the presence of increased concentrations of glucose and galactose. Killing was abolished in 50 mmol/l glucose and 10 and 50 mmol/l galactose. The oxidative phase of killing was examined using lucigenin-enhanced chemiluminescence. An increase in glucose concentration from 5 to 50 mmol/l produced a fall in chemiluminescence output from 128.5 +/- 16.8 (mean +/- SE) to 82.2 +/- 9.8 mV min (a reduction of 36%). These data suggest the existence of aldose reductase activity in neutrophils and using gas chromatography we have demonstrated the presence of sorbitol in extracts of diabetic neutrophils. As oxidative killing and sorbitol production are both NADPH-dependent the inhibition of killing is likely to be due to competition for this electron donor. This abnormality of neutrophil function may aggravate various infections in the patient with diabetes." @default.
- W2035449853 created "2016-06-24" @default.
- W2035449853 creator A5057795207 @default.
- W2035449853 creator A5084134380 @default.
- W2035449853 creator A5085026779 @default.
- W2035449853 date "1987-01-02" @default.
- W2035449853 modified "2023-10-16" @default.
- W2035449853 title "Neutrophil Sorbitol Production Impairs Oxidative Killing in Diabetes" @default.
- W2035449853 cites W1480967651 @default.
- W2035449853 cites W1968404867 @default.
- W2035449853 cites W1969488647 @default.
- W2035449853 cites W1970122264 @default.
- W2035449853 cites W1973895615 @default.
- W2035449853 cites W1984623452 @default.
- W2035449853 cites W1986346567 @default.
- W2035449853 cites W2037044220 @default.
- W2035449853 cites W2037535348 @default.
- W2035449853 cites W2078444872 @default.
- W2035449853 cites W4240067695 @default.
- W2035449853 cites W4241553305 @default.
- W2035449853 doi "https://doi.org/10.1111/j.1464-5491.1987.tb00825.x" @default.
- W2035449853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2951217" @default.
- W2035449853 hasPublicationYear "1987" @default.
- W2035449853 type Work @default.
- W2035449853 sameAs 2035449853 @default.
- W2035449853 citedByCount "59" @default.
- W2035449853 countsByYear W20354498532012 @default.
- W2035449853 countsByYear W20354498532013 @default.
- W2035449853 countsByYear W20354498532014 @default.
- W2035449853 countsByYear W20354498532015 @default.
- W2035449853 countsByYear W20354498532016 @default.
- W2035449853 countsByYear W20354498532017 @default.
- W2035449853 countsByYear W20354498532019 @default.
- W2035449853 countsByYear W20354498532022 @default.
- W2035449853 crossrefType "journal-article" @default.
- W2035449853 hasAuthorship W2035449853A5057795207 @default.
- W2035449853 hasAuthorship W2035449853A5084134380 @default.
- W2035449853 hasAuthorship W2035449853A5085026779 @default.
- W2035449853 hasConcept C126322002 @default.
- W2035449853 hasConcept C134018914 @default.
- W2035449853 hasConcept C136502266 @default.
- W2035449853 hasConcept C145802702 @default.
- W2035449853 hasConcept C181199279 @default.
- W2035449853 hasConcept C185592680 @default.
- W2035449853 hasConcept C198677920 @default.
- W2035449853 hasConcept C2776151105 @default.
- W2035449853 hasConcept C2776439734 @default.
- W2035449853 hasConcept C2776779347 @default.
- W2035449853 hasConcept C2776914184 @default.
- W2035449853 hasConcept C2778173381 @default.
- W2035449853 hasConcept C2779127771 @default.
- W2035449853 hasConcept C2780795997 @default.
- W2035449853 hasConcept C43617362 @default.
- W2035449853 hasConcept C55493867 @default.
- W2035449853 hasConcept C555293320 @default.
- W2035449853 hasConcept C57600042 @default.
- W2035449853 hasConcept C71924100 @default.
- W2035449853 hasConcept C86803240 @default.
- W2035449853 hasConceptScore W2035449853C126322002 @default.
- W2035449853 hasConceptScore W2035449853C134018914 @default.
- W2035449853 hasConceptScore W2035449853C136502266 @default.
- W2035449853 hasConceptScore W2035449853C145802702 @default.
- W2035449853 hasConceptScore W2035449853C181199279 @default.
- W2035449853 hasConceptScore W2035449853C185592680 @default.
- W2035449853 hasConceptScore W2035449853C198677920 @default.
- W2035449853 hasConceptScore W2035449853C2776151105 @default.
- W2035449853 hasConceptScore W2035449853C2776439734 @default.
- W2035449853 hasConceptScore W2035449853C2776779347 @default.
- W2035449853 hasConceptScore W2035449853C2776914184 @default.
- W2035449853 hasConceptScore W2035449853C2778173381 @default.
- W2035449853 hasConceptScore W2035449853C2779127771 @default.
- W2035449853 hasConceptScore W2035449853C2780795997 @default.
- W2035449853 hasConceptScore W2035449853C43617362 @default.
- W2035449853 hasConceptScore W2035449853C55493867 @default.
- W2035449853 hasConceptScore W2035449853C555293320 @default.
- W2035449853 hasConceptScore W2035449853C57600042 @default.
- W2035449853 hasConceptScore W2035449853C71924100 @default.
- W2035449853 hasConceptScore W2035449853C86803240 @default.
- W2035449853 hasIssue "1" @default.
- W2035449853 hasLocation W20354498531 @default.
- W2035449853 hasLocation W20354498532 @default.
- W2035449853 hasOpenAccess W2035449853 @default.
- W2035449853 hasPrimaryLocation W20354498531 @default.
- W2035449853 hasRelatedWork W1804813305 @default.
- W2035449853 hasRelatedWork W1983754683 @default.
- W2035449853 hasRelatedWork W2002081092 @default.
- W2035449853 hasRelatedWork W2058413748 @default.
- W2035449853 hasRelatedWork W2060387409 @default.
- W2035449853 hasRelatedWork W2124306225 @default.
- W2035449853 hasRelatedWork W2143902746 @default.
- W2035449853 hasRelatedWork W2412204388 @default.
- W2035449853 hasRelatedWork W2418633302 @default.
- W2035449853 hasRelatedWork W79560055 @default.
- W2035449853 hasVolume "4" @default.
- W2035449853 isParatext "false" @default.
- W2035449853 isRetracted "false" @default.
- W2035449853 magId "2035449853" @default.
- W2035449853 workType "article" @default.