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- W20354567 abstract "Publisher Summary This chapter discusses the oxidation of hypotaurine in brain and liver of developing mice. Hypotaurine, 2-aminoethanesulfonic acid, is apparently the immediate precursor of the corresponding sulfonic acid, taurine, a possible neuromodulator. The chapter discusses a study of the subcellular distribution of [35S]hypotaurine oxidation with 7-day-old mice. In the liver, both microsomes and soluble cytoplasma contained 30 to 40% of the total activity, the rest being equally distributed in the nuclei and mitochondria. In the brain, about three-fourths were recovered in the soluble cytoplasma; the nuclei and mitochondria (synaptosomes included) contained as much as in the liver, but the microsomes were almost devoid of activity. In the liver, the oxidation rate increased during the first 9 postnatal days, declining gradually thereafter. In the brain, two activity maxima were at 2–6 days and at about 3 weeks of age, respectively. The results obtained in this study show that taurine can be formed enzymatically from hypotaurine in the mouse." @default.
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- W20354567 modified "2023-09-23" @default.
- W20354567 title "OXIDATION OF HYPOTAURINE IN BRAIN AND LIVER OF DEVELOPING MICE" @default.
- W20354567 doi "https://doi.org/10.1016/b978-0-08-025921-5.50030-8" @default.
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