FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035462576> ?p ?o ?g. }

• W2035462576 endingPage "634" @default.
• W2035462576 startingPage "629" @default.
• W2035462576 abstract "Verrucous carcinoma (VC), a variant of squamous cell carcinoma (SCC), is distinct from SCC in morphology and behavior. The underlying genetic changes involved in the development of VC and its precursor verrucous hyperplasia (VH) are unknown. This study determined whether chromosomal regions frequently lost during the development of SCC are also lost in the VH/VC variant. Twenty-five VH and 17 VC were analyzed for loss of heterozygosity (LOH) at 19 loci on 7 chromosome arms using microsatellite analysis. These data were compared with those from 47 reactive hyperplasias, 92 dysplasias (54 low- and 38 high-grade), and 41 SCCs. The results showed that VC/VH shared many of the losses present in dysplasia/SCC but differed in two aspects. First, VC/VH showed early acquisition of loss, compared with a gradual accumulation of losses from dysplasias to SCC. The LOH pattern of VH was similar to that of high-grade dysplasia and sharply different from reactive hyperplasia. The loss in VH often involved multiple arms (in 60% of VH vs 0% of reactive lesions). Only a marginal elevation of loss was observed at 9p (p = 0.06) and 4q (p = 0.05) from VH to VC because of the high degree of loss already present in VH. Second, a strikingly lower frequency of loss at 17p was noted in VH/VC compared with dysplasia/SCC and may indicate human papillomavirus (HPV) involvement. The finding of high-risk LOH profiles in VH may partly account for the high-progression risk seen for VH and also has potentially important clinical implications. The difficult pathological diagnosis of VH/VC from reactive hyperplasia frequently requires repeated biopsies and results in delay in diagnosis and significantly increased mortality/morbidity. Microsatellite analysis might facilitate this differential diagnosis." @default.
• W2035462576 created "2016-06-24" @default.
• W2035462576 creator A5005397547 @default.
• W2035462576 creator A5013908616 @default.
• W2035462576 creator A5033528539 @default.
• W2035462576 creator A5040861518 @default.
• W2035462576 creator A5060238314 @default.
• W2035462576 creator A5061656649 @default.
• W2035462576 creator A5061757934 @default.
• W2035462576 creator A5061809819 @default.
• W2035462576 creator A5089589253 @default.
• W2035462576 date "2001-04-01" @default.
• W2035462576 modified "2023-10-18" @default.
• W2035462576 title "A High Frequency of Allelic Loss in Oral Verrucous Lesions May Explain Malignant Risk" @default.
• W2035462576 cites W1519633462 @default.
• W2035462576 cites W186393050 @default.
• W2035462576 cites W1963625854 @default.
• W2035462576 cites W1974602525 @default.
• W2035462576 cites W1978800919 @default.
• W2035462576 cites W1987098700 @default.
• W2035462576 cites W1992713339 @default.
• W2035462576 cites W1996017378 @default.
• W2035462576 cites W1997148030 @default.
• W2035462576 cites W1999349058 @default.
• W2035462576 cites W2002534518 @default.
• W2035462576 cites W2032569099 @default.
• W2035462576 cites W2039955640 @default.
• W2035462576 cites W2040017091 @default.
• W2035462576 cites W2043348085 @default.
• W2035462576 cites W2076119363 @default.
• W2035462576 cites W2086698289 @default.
• W2035462576 cites W2088084016 @default.
• W2035462576 cites W2088965948 @default.
• W2035462576 cites W2140796606 @default.
• W2035462576 cites W2149166037 @default.
• W2035462576 cites W4239327307 @default.
• W2035462576 cites W4246185811 @default.
• W2035462576 doi "https://doi.org/10.1038/labinvest.3780271" @default.
• W2035462576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11304582" @default.
• W2035462576 hasPublicationYear "2001" @default.
• W2035462576 type Work @default.
• W2035462576 sameAs 2035462576 @default.
• W2035462576 citedByCount "48" @default.
• W2035462576 countsByYear W20354625762012 @default.
• W2035462576 countsByYear W20354625762014 @default.
• W2035462576 countsByYear W20354625762015 @default.
• W2035462576 countsByYear W20354625762016 @default.
• W2035462576 countsByYear W20354625762017 @default.
• W2035462576 countsByYear W20354625762021 @default.
• W2035462576 countsByYear W20354625762022 @default.
• W2035462576 crossrefType "journal-article" @default.
• W2035462576 hasAuthorship W2035462576A5005397547 @default.
• W2035462576 hasAuthorship W2035462576A5013908616 @default.
• W2035462576 hasAuthorship W2035462576A5033528539 @default.
• W2035462576 hasAuthorship W2035462576A5040861518 @default.
• W2035462576 hasAuthorship W2035462576A5060238314 @default.
• W2035462576 hasAuthorship W2035462576A5061656649 @default.
• W2035462576 hasAuthorship W2035462576A5061757934 @default.
• W2035462576 hasAuthorship W2035462576A5061809819 @default.
• W2035462576 hasAuthorship W2035462576A5089589253 @default.
• W2035462576 hasBestOaLocation W20354625761 @default.
• W2035462576 hasConcept C104317684 @default.
• W2035462576 hasConcept C142724271 @default.
• W2035462576 hasConcept C143589142 @default.
• W2035462576 hasConcept C180754005 @default.
• W2035462576 hasConcept C2775894508 @default.
• W2035462576 hasConcept C2776034340 @default.
• W2035462576 hasConcept C2777546739 @default.
• W2035462576 hasConcept C2777562237 @default.
• W2035462576 hasConcept C54355233 @default.
• W2035462576 hasConcept C71924100 @default.
• W2035462576 hasConcept C86803240 @default.
• W2035462576 hasConceptScore W2035462576C104317684 @default.
• W2035462576 hasConceptScore W2035462576C142724271 @default.
• W2035462576 hasConceptScore W2035462576C143589142 @default.
• W2035462576 hasConceptScore W2035462576C180754005 @default.
• W2035462576 hasConceptScore W2035462576C2775894508 @default.
• W2035462576 hasConceptScore W2035462576C2776034340 @default.
• W2035462576 hasConceptScore W2035462576C2777546739 @default.
• W2035462576 hasConceptScore W2035462576C2777562237 @default.
• W2035462576 hasConceptScore W2035462576C54355233 @default.
• W2035462576 hasConceptScore W2035462576C71924100 @default.
• W2035462576 hasConceptScore W2035462576C86803240 @default.
• W2035462576 hasIssue "4" @default.
• W2035462576 hasLocation W20354625761 @default.
• W2035462576 hasLocation W20354625762 @default.
• W2035462576 hasOpenAccess W2035462576 @default.
• W2035462576 hasPrimaryLocation W20354625761 @default.
• W2035462576 hasRelatedWork W10967267 @default.
• W2035462576 hasRelatedWork W2001734836 @default.
• W2035462576 hasRelatedWork W2007389278 @default.
• W2035462576 hasRelatedWork W2331822226 @default.
• W2035462576 hasRelatedWork W2353484916 @default.
• W2035462576 hasRelatedWork W2404120231 @default.
• W2035462576 hasRelatedWork W2414346359 @default.
• W2035462576 hasRelatedWork W2414485083 @default.
• W2035462576 hasRelatedWork W3119340568 @default.
• W2035462576 hasRelatedWork W2210367328 @default.

• next