Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035462701> ?p ?o ?g. }
- W2035462701 abstract "Nutritional factors, as sources of luminal antigens, have been thought to be important factors in the immunopathogenesis of numerous gastrointestinal diseases. In some diseases, the role of the nutritional component is causal in the susceptible host. Such diseases include celiac disease, a common heritable chronic inflammatory condition of the small intestine induced by dietary wheat, rye and barley, in susceptible individuals. Specific HLA-DQ2 and HLA-DQ8 risk alleles are necessary, but not sufficient, for disease development. The well-defined role of HLA-DQ heterodimers encoded by these alleles is to present cereal peptides to CD4+ T cells, activating an inflammatory immune response in the intestine. Genome-wide association studies have been performed which identified the IL2-IL21 risk locus and other genes with immune functions and key roles in thymic T-cell selection. Another example for this group is Wilson's disease, an autosomal recessive disorder of copper metabolism caused by mutation of the ATP7B gene, resulting in a defect of biliary copper excretion and toxic accumulation in the body, especially in the liver, brain and cornea, resulting in hepatic and/or neurological symptoms. In other diseases, however, the association is less well established. In such endeavor, epidemiological observations may become a valuable part of the overall investigations aimed at identifying dietary factors, which are involved in the initiation and perpetuation of the specific disease. As an example, relationships between nutrition and colorectal cancer have been hypothesized early on (e.g. folate, calcium, vitamin D, red meat). Similarly, intake of certain diet constituents like fat, refined sugar, fruits, vegetables and fiber was reported to be associated with the expression of inflammatory bowel diseases. In addition, in children with active Crohn's disease, enteral nutrition was found to be equally effective as corticosteroids in induction of remission, with mucosal healing induced by downregulation of mucosal pro-inflammatory cytokine profiles in both the ileum and the colon after enteral nutrition. However, the particular effect of the consumption of each type of food remains questionable in most cases, at least in part because of insufficient data and serious methodological limitations (e.g. recall bias, heterogeneity between collected data, lack of correction for covariates, difficulties in double blinding)." @default.
- W2035462701 created "2016-06-24" @default.
- W2035462701 creator A5036036179 @default.
- W2035462701 creator A5046070636 @default.
- W2035462701 creator A5069815531 @default.
- W2035462701 date "2011-01-01" @default.
- W2035462701 modified "2023-09-26" @default.
- W2035462701 title "Nutritional Influences in Selected Gastrointestinal Diseases" @default.
- W2035462701 cites W1500371449 @default.
- W2035462701 cites W1531267945 @default.
- W2035462701 cites W1581727317 @default.
- W2035462701 cites W1585085258 @default.
- W2035462701 cites W1899913413 @default.
- W2035462701 cites W1965424464 @default.
- W2035462701 cites W1966143778 @default.
- W2035462701 cites W1975703712 @default.
- W2035462701 cites W1977111258 @default.
- W2035462701 cites W1980368148 @default.
- W2035462701 cites W1983723576 @default.
- W2035462701 cites W1987184215 @default.
- W2035462701 cites W1987306123 @default.
- W2035462701 cites W1987447778 @default.
- W2035462701 cites W1991478615 @default.
- W2035462701 cites W1993337379 @default.
- W2035462701 cites W1995611431 @default.
- W2035462701 cites W1996610030 @default.
- W2035462701 cites W1997917153 @default.
- W2035462701 cites W1999600031 @default.
- W2035462701 cites W2002023508 @default.
- W2035462701 cites W2006510543 @default.
- W2035462701 cites W2010298873 @default.
- W2035462701 cites W2014540972 @default.
- W2035462701 cites W2024544489 @default.
- W2035462701 cites W2026644677 @default.
- W2035462701 cites W2028145032 @default.
- W2035462701 cites W2030947586 @default.
- W2035462701 cites W2031579849 @default.
- W2035462701 cites W2032295699 @default.
- W2035462701 cites W2039591213 @default.
- W2035462701 cites W2042775035 @default.
- W2035462701 cites W2043221183 @default.
- W2035462701 cites W2052297423 @default.
- W2035462701 cites W2052905295 @default.
- W2035462701 cites W2053022118 @default.
- W2035462701 cites W2054969598 @default.
- W2035462701 cites W2055157166 @default.
- W2035462701 cites W2059439467 @default.
- W2035462701 cites W2059935861 @default.
- W2035462701 cites W2066012572 @default.
- W2035462701 cites W2066845511 @default.
- W2035462701 cites W2067104364 @default.
- W2035462701 cites W2074150842 @default.
- W2035462701 cites W2079522949 @default.
- W2035462701 cites W2086136703 @default.
- W2035462701 cites W2086796885 @default.
- W2035462701 cites W2087824865 @default.
- W2035462701 cites W2088045986 @default.
- W2035462701 cites W2089239904 @default.
- W2035462701 cites W2089627752 @default.
- W2035462701 cites W2090742607 @default.
- W2035462701 cites W2092826164 @default.
- W2035462701 cites W2097903769 @default.
- W2035462701 cites W2097939264 @default.
- W2035462701 cites W2098177537 @default.
- W2035462701 cites W2102055578 @default.
- W2035462701 cites W2104029723 @default.
- W2035462701 cites W2107963470 @default.
- W2035462701 cites W2109544293 @default.
- W2035462701 cites W2112136965 @default.
- W2035462701 cites W2112182790 @default.
- W2035462701 cites W2112409097 @default.
- W2035462701 cites W2113665122 @default.
- W2035462701 cites W2114555183 @default.
- W2035462701 cites W2118913969 @default.
- W2035462701 cites W2119330774 @default.
- W2035462701 cites W2123411656 @default.
- W2035462701 cites W2124435321 @default.
- W2035462701 cites W2124795500 @default.
- W2035462701 cites W2125555008 @default.
- W2035462701 cites W2130157754 @default.
- W2035462701 cites W2133242260 @default.
- W2035462701 cites W2133547370 @default.
- W2035462701 cites W2134359770 @default.
- W2035462701 cites W2136125035 @default.
- W2035462701 cites W2139288503 @default.
- W2035462701 cites W2139477740 @default.
- W2035462701 cites W2148018015 @default.
- W2035462701 cites W2149991913 @default.
- W2035462701 cites W2151351671 @default.
- W2035462701 cites W2151972971 @default.
- W2035462701 cites W2158199641 @default.
- W2035462701 cites W2158579203 @default.
- W2035462701 cites W2165608495 @default.
- W2035462701 cites W2167370693 @default.
- W2035462701 cites W2169957220 @default.
- W2035462701 cites W2327515496 @default.
- W2035462701 cites W2328253827 @default.
- W2035462701 cites W2336342927 @default.
- W2035462701 cites W2986234337 @default.
- W2035462701 cites W3023703118 @default.