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- W2035464686 abstract "To rigorously determine whether a gene or a set of genes have alterations that are involved in carcinogenesis requires a comparison of the prevalence of identified changes to a control mutation frequency present in tumor DNA. To facilitate this task, we develop a testing approach and the associated R library, called TRAB, that evaluates whether the frequency of somatic mutation in a given gene is higher than that observed in a control group of genes. Specifically, we test the null hypothesis that the frequency belongs to a control population of frequencies, against the alternative hypothesis that the frequency is higher. Mutation frequencies in the control group are themselves allowed to be variable. TRAB computes the a posteriori probability and the Bayes factor for the hypothesis using a hierarchical Bayesian approach." @default.
- W2035464686 created "2016-06-24" @default.
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- W2035464686 date "2008-01-14" @default.
- W2035464686 modified "2023-09-26" @default.
- W2035464686 title "TRAB: Testing Whether Mutation Frequencies Are Above an Unknown Background" @default.
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- W2035464686 doi "https://doi.org/10.2202/1544-6115.1277" @default.
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