Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035474183> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2035474183 endingPage "3350" @default.
- W2035474183 startingPage "3346" @default.
- W2035474183 abstract "To study the toxicokinetics in severe chloroquine poisoning, and to evaluate the efficacy of hemoperfusion.Case report on one observation.Medical intensive care unit (ICU) of the University Medical Center Utrecht, The Netherlands.A previously healthy, 52-yr-old woman ingested 100 tablets containing 100 mg chloroquine base 1 hr before admission. At admission, she was drowsy, agitated, hypotensive, and in respiratory distress. Shortly thereafter, she was resuscitated from cardiac arrest. After hemodynamic and respiratory stabilization, the patient was transferred to the medical ICU. TOXICOKINETICS EVALUATION: During the course of her stay at the ICU, blood samples were taken for the determination of chloroquine and the metabolite desethylchloroquine concentration. Hemoperfusion was started 3.5 hrs after ingestion of the chloroquine tablets.The following toxicokinetics data during this severe chloroquine poisoning were calculated: apparent volume of the central compartment 181 L, apparent volume of distribution 1137 L, half-life in the distribution phase 6.4 hrs, half-life in the elimination phase 392.8 hrs, and total body clearance 2.01 L/hour. The average extraction ratio during hemoperfusion was 0.07, 0.28, and 0.25, in plasma, erythrocytes and whole blood, respectively. The total amount of chloroquine removed by hemoperfusion was only 480 mg (5.3% of the amount ingested). Simulation of a hemoperfusion session over 5 hrs by using a column with an optimal extraction ratio of 1.0 would have removed 1,816 mg chloroquine, only 18.2% of the amount ingested. This limited contribution of hemoperfusion to the total clearance makes it ineffective.Hemoperfusion is not effective in severe chloroquine poisoning, even when started (relatively) early in the course of the intoxication. Toxicokinetic evaluation of a chloroquine poisoning should be based on the evaluation of plasma and whole blood concentrations." @default.
- W2035474183 created "2016-06-24" @default.
- W2035474183 creator A5019022094 @default.
- W2035474183 creator A5036646443 @default.
- W2035474183 creator A5048111329 @default.
- W2035474183 creator A5065877848 @default.
- W2035474183 date "2000-09-01" @default.
- W2035474183 modified "2023-09-23" @default.
- W2035474183 title "Hemoperfusion is ineffectual in severe chloroquine poisoning" @default.
- W2035474183 cites W1057109913 @default.
- W2035474183 cites W1964936470 @default.
- W2035474183 cites W1968199422 @default.
- W2035474183 cites W1971887376 @default.
- W2035474183 cites W1978596641 @default.
- W2035474183 cites W1978715187 @default.
- W2035474183 cites W1994647659 @default.
- W2035474183 cites W2023174165 @default.
- W2035474183 cites W2055877540 @default.
- W2035474183 cites W2116565315 @default.
- W2035474183 cites W2130940056 @default.
- W2035474183 cites W2336714276 @default.
- W2035474183 cites W4206711969 @default.
- W2035474183 doi "https://doi.org/10.1097/00003246-200009000-00040" @default.
- W2035474183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11009001" @default.
- W2035474183 hasPublicationYear "2000" @default.
- W2035474183 type Work @default.
- W2035474183 sameAs 2035474183 @default.
- W2035474183 citedByCount "20" @default.
- W2035474183 countsByYear W20354741832014 @default.
- W2035474183 countsByYear W20354741832015 @default.
- W2035474183 countsByYear W20354741832016 @default.
- W2035474183 countsByYear W20354741832017 @default.
- W2035474183 countsByYear W20354741832019 @default.
- W2035474183 countsByYear W20354741832020 @default.
- W2035474183 countsByYear W20354741832021 @default.
- W2035474183 crossrefType "journal-article" @default.
- W2035474183 hasAuthorship W2035474183A5019022094 @default.
- W2035474183 hasAuthorship W2035474183A5036646443 @default.
- W2035474183 hasAuthorship W2035474183A5048111329 @default.
- W2035474183 hasAuthorship W2035474183A5065877848 @default.
- W2035474183 hasConcept C112705442 @default.
- W2035474183 hasConcept C126322002 @default.
- W2035474183 hasConcept C139254425 @default.
- W2035474183 hasConcept C141071460 @default.
- W2035474183 hasConcept C195289149 @default.
- W2035474183 hasConcept C203014093 @default.
- W2035474183 hasConcept C2776376669 @default.
- W2035474183 hasConcept C2777425658 @default.
- W2035474183 hasConcept C2778048844 @default.
- W2035474183 hasConcept C2778063415 @default.
- W2035474183 hasConcept C2781123077 @default.
- W2035474183 hasConcept C42219234 @default.
- W2035474183 hasConcept C71924100 @default.
- W2035474183 hasConcept C98274493 @default.
- W2035474183 hasConceptScore W2035474183C112705442 @default.
- W2035474183 hasConceptScore W2035474183C126322002 @default.
- W2035474183 hasConceptScore W2035474183C139254425 @default.
- W2035474183 hasConceptScore W2035474183C141071460 @default.
- W2035474183 hasConceptScore W2035474183C195289149 @default.
- W2035474183 hasConceptScore W2035474183C203014093 @default.
- W2035474183 hasConceptScore W2035474183C2776376669 @default.
- W2035474183 hasConceptScore W2035474183C2777425658 @default.
- W2035474183 hasConceptScore W2035474183C2778048844 @default.
- W2035474183 hasConceptScore W2035474183C2778063415 @default.
- W2035474183 hasConceptScore W2035474183C2781123077 @default.
- W2035474183 hasConceptScore W2035474183C42219234 @default.
- W2035474183 hasConceptScore W2035474183C71924100 @default.
- W2035474183 hasConceptScore W2035474183C98274493 @default.
- W2035474183 hasIssue "9" @default.
- W2035474183 hasLocation W20354741831 @default.
- W2035474183 hasLocation W20354741832 @default.
- W2035474183 hasOpenAccess W2035474183 @default.
- W2035474183 hasPrimaryLocation W20354741831 @default.
- W2035474183 hasRelatedWork W1962082601 @default.
- W2035474183 hasRelatedWork W1971887376 @default.
- W2035474183 hasRelatedWork W2009510136 @default.
- W2035474183 hasRelatedWork W2035474183 @default.
- W2035474183 hasRelatedWork W2043778609 @default.
- W2035474183 hasRelatedWork W2148177218 @default.
- W2035474183 hasRelatedWork W2154326312 @default.
- W2035474183 hasRelatedWork W2264246004 @default.
- W2035474183 hasRelatedWork W2463077557 @default.
- W2035474183 hasRelatedWork W2770888081 @default.
- W2035474183 hasVolume "28" @default.
- W2035474183 isParatext "false" @default.
- W2035474183 isRetracted "false" @default.
- W2035474183 magId "2035474183" @default.
- W2035474183 workType "article" @default.