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- W2035476626 abstract "Adrenomedullin (ADM), a 52-amino acid ringed-structure peptide with C-terminal amidation, was originally isolated from human pheochromocytoma. ADM mediates vasodilatory and natriuretic properties through the second messenger cyclic adenosine 3',5'-monophosphate (cAMP), nitric oxide and the renal prostaglandin system. ADM immunoreactivity and its gene are widely distributed in cardiovascular, pulmonary, renal, gastrointestinal, cerebral and endocrine tissues. ADM is also synthesized and secreted from vascular endothelial and smooth muscle cells. When injected intravenously, ADM increases flow rates predominantly in organs in which the ADM gene is highly expressed, suggesting that ADM acts as a local autocrine and/or paracrine vasoactive hormone. In addition, ADM is a circulating hormone and its plasma concentration is increased in various cardiorenal diseases such as hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM plays an important role in fluid and electrolyte homeostasis and cardiorenal regulation, however further investigations are required to address the importance of ADM under various physiological and pathophysiological conditions." @default.
- W2035476626 created "2016-06-24" @default.
- W2035476626 creator A5000837120 @default.
- W2035476626 creator A5014193048 @default.
- W2035476626 date "2000-01-01" @default.
- W2035476626 modified "2023-10-18" @default.
- W2035476626 title "Adrenomedullin: Potential in physiology and pathophysiology" @default.
- W2035476626 cites W108727682 @default.
- W2035476626 cites W1710479331 @default.
- W2035476626 cites W1889958256 @default.
- W2035476626 cites W1942168762 @default.
- W2035476626 cites W1965121261 @default.
- W2035476626 cites W1965850532 @default.
- W2035476626 cites W1968082239 @default.
- W2035476626 cites W1968184150 @default.
- W2035476626 cites W1968612623 @default.
- W2035476626 cites W1970314104 @default.
- W2035476626 cites W1971827528 @default.
- W2035476626 cites W1972441205 @default.
- W2035476626 cites W1981492597 @default.
- W2035476626 cites W1982290807 @default.
- W2035476626 cites W1985032866 @default.
- W2035476626 cites W1987243059 @default.
- W2035476626 cites W1987989887 @default.
- W2035476626 cites W1989215465 @default.
- W2035476626 cites W1990927850 @default.
- W2035476626 cites W1991665944 @default.
- W2035476626 cites W1992526453 @default.
- W2035476626 cites W1994122816 @default.
- W2035476626 cites W1994134980 @default.
- W2035476626 cites W1997318258 @default.
- W2035476626 cites W1999476790 @default.
- W2035476626 cites W2002017720 @default.
- W2035476626 cites W2002253280 @default.
- W2035476626 cites W2003624432 @default.
- W2035476626 cites W2003671607 @default.
- W2035476626 cites W2003978655 @default.
- W2035476626 cites W2003986516 @default.
- W2035476626 cites W2004887716 @default.
- W2035476626 cites W2006220524 @default.
- W2035476626 cites W2006552834 @default.
- W2035476626 cites W2008150243 @default.
- W2035476626 cites W2013928270 @default.
- W2035476626 cites W2018239935 @default.
- W2035476626 cites W2019265025 @default.
- W2035476626 cites W2021256963 @default.
- W2035476626 cites W2021732047 @default.
- W2035476626 cites W2022333002 @default.
- W2035476626 cites W2023178307 @default.
- W2035476626 cites W2023541036 @default.
- W2035476626 cites W2030064280 @default.
- W2035476626 cites W2033697164 @default.
- W2035476626 cites W2034127105 @default.
- W2035476626 cites W2036718643 @default.
- W2035476626 cites W2037088389 @default.
- W2035476626 cites W2038282796 @default.
- W2035476626 cites W2038377136 @default.
- W2035476626 cites W2039784024 @default.
- W2035476626 cites W2042657041 @default.
- W2035476626 cites W2043034527 @default.
- W2035476626 cites W2045564542 @default.
- W2035476626 cites W2046572176 @default.
- W2035476626 cites W2046787212 @default.
- W2035476626 cites W2046964201 @default.
- W2035476626 cites W2048988471 @default.
- W2035476626 cites W2053731747 @default.
- W2035476626 cites W2053809255 @default.
- W2035476626 cites W2055860851 @default.
- W2035476626 cites W2056490759 @default.
- W2035476626 cites W2058370690 @default.
- W2035476626 cites W2059498581 @default.
- W2035476626 cites W2061114894 @default.
- W2035476626 cites W2062599117 @default.
- W2035476626 cites W2065175932 @default.
- W2035476626 cites W2066837470 @default.
- W2035476626 cites W2068292866 @default.
- W2035476626 cites W2068727683 @default.
- W2035476626 cites W2069199634 @default.
- W2035476626 cites W2070125125 @default.
- W2035476626 cites W2071022286 @default.
- W2035476626 cites W2071475512 @default.
- W2035476626 cites W2071577747 @default.
- W2035476626 cites W2074295150 @default.
- W2035476626 cites W2076584521 @default.
- W2035476626 cites W2077886050 @default.
- W2035476626 cites W2080134716 @default.
- W2035476626 cites W2081267816 @default.
- W2035476626 cites W2083381610 @default.
- W2035476626 cites W2085036948 @default.
- W2035476626 cites W2086378672 @default.
- W2035476626 cites W2087956146 @default.
- W2035476626 cites W2089893988 @default.
- W2035476626 cites W2092419989 @default.
- W2035476626 cites W2094958645 @default.
- W2035476626 cites W2095354033 @default.
- W2035476626 cites W2098483384 @default.
- W2035476626 cites W2111112233 @default.
- W2035476626 cites W2112386761 @default.