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• W2035477757 abstract "Multidrug resistance (MDR) is the main barrier to the success of chemotherapy for gastric cancer (GC). miR-106a, which is highly expressed in GC, influences a variety of aspects of GC. However, the function of miR-106a in MDR of GC still remains unclear. In the present study, we found that miR-106a is elevated in MDR cell lines. miR-106a promotes chemo-resistance of GC cells, accelerates ADR efflux, and suppresses drug-induced apoptosis. Finally, we show that runt-related trans factor 3 (RUNX3) is the functional target of miR-106a. Collectively, these findings demonstrate that miR-106a may promote MDR in GC cells by targeting RUNX3." @default.
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• W2035477757 date "2013-08-07" @default.
• W2035477757 modified "2023-10-03" @default.
• W2035477757 title "MicroRNA-106a induces multidrug resistance in gastric cancer by targeting RUNX3" @default.
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• W2035477757 doi "https://doi.org/10.1016/j.febslet.2013.06.058" @default.
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