FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035485568> ?p ?o ?g. }

• W2035485568 endingPage "6135" @default.
• W2035485568 startingPage "6125" @default.
• W2035485568 abstract "USF and c-Myc are basic helix–loop–helix transcription factors with similar DNA-binding specificities, but antagonistic effects on cellular transformation. In order to determine how these opposite functions correlate with the transcriptional activities of the two factors on particular downstream targets, we investigated the roles of USF and c-Myc in expression of CDK4, a known direct target of c-Myc. Overexpression of either c-Myc or USF2, but not USF1, stimulated the expression of CDK4 promoter-driven reporter genes in the non-tumorigenic mammary epithelial MCF-10A cells. Dominant-negative mutants specific to either Myc or USF family proteins inhibited reporter gene activity as well as endogenous CDK4 expression, demonstrating involvement of both USF and Myc in CDK4 transcriptional control. In contrast, in two different breast cancer cell lines where USF is transcriptionally inactive and c-Myc is overexpressed, CDK4 promoter activity was no longer responsive to either transcription factor. Accordingly, chromatin immunoprecipitation revealed significantly lower levels of both USF and c-Myc bound to the endogenous CDK4 promoter in breast cancer cells than in MCF-10A cells, with a concomitant decrease in associated histone H3 acetylation. These results suggest that a major switch in the transcriptional control of CDK4 occurs during breast carcinogenesis, with likely alteration of cell cycle regulation." @default.
• W2035485568 created "2016-06-24" @default.
• W2035485568 creator A5018105714 @default.
• W2035485568 creator A5072182165 @default.
• W2035485568 creator A5083350316 @default.
• W2035485568 creator A5085248591 @default.
• W2035485568 date "2004-06-21" @default.
• W2035485568 modified "2023-09-27" @default.
• W2035485568 title "Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc" @default.
• W2035485568 cites W128302075 @default.
• W2035485568 cites W1515792029 @default.
• W2035485568 cites W1520222296 @default.
• W2035485568 cites W1835811284 @default.
• W2035485568 cites W1869102274 @default.
• W2035485568 cites W1906271222 @default.
• W2035485568 cites W1932315029 @default.
• W2035485568 cites W1963091570 @default.
• W2035485568 cites W1965226888 @default.
• W2035485568 cites W1969255091 @default.
• W2035485568 cites W1990925999 @default.
• W2035485568 cites W1991693950 @default.
• W2035485568 cites W1992595091 @default.
• W2035485568 cites W1995930786 @default.
• W2035485568 cites W1996413533 @default.
• W2035485568 cites W2002575581 @default.
• W2035485568 cites W2013454002 @default.
• W2035485568 cites W2013545583 @default.
• W2035485568 cites W2023063327 @default.
• W2035485568 cites W2040193953 @default.
• W2035485568 cites W2048555922 @default.
• W2035485568 cites W2053879589 @default.
• W2035485568 cites W2064879069 @default.
• W2035485568 cites W2074425666 @default.
• W2035485568 cites W2079133548 @default.
• W2035485568 cites W2084753863 @default.
• W2035485568 cites W2086778920 @default.
• W2035485568 cites W2089218510 @default.
• W2035485568 cites W2092106935 @default.
• W2035485568 cites W2095048284 @default.
• W2035485568 cites W2097774235 @default.
• W2035485568 cites W2121619780 @default.
• W2035485568 cites W2124963418 @default.
• W2035485568 cites W2125027386 @default.
• W2035485568 cites W2125267517 @default.
• W2035485568 cites W2132299936 @default.
• W2035485568 cites W2139102988 @default.
• W2035485568 cites W2150868953 @default.
• W2035485568 cites W2161137230 @default.
• W2035485568 cites W2161762726 @default.
• W2035485568 cites W2171852242 @default.
• W2035485568 cites W2312271862 @default.
• W2035485568 cites W3213154483 @default.
• W2035485568 cites W4235042226 @default.
• W2035485568 doi "https://doi.org/10.1038/sj.onc.1207806" @default.
• W2035485568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15208653" @default.
• W2035485568 hasPublicationYear "2004" @default.
• W2035485568 type Work @default.
• W2035485568 sameAs 2035485568 @default.
• W2035485568 citedByCount "30" @default.
• W2035485568 countsByYear W20354855682012 @default.
• W2035485568 countsByYear W20354855682015 @default.
• W2035485568 countsByYear W20354855682016 @default.
• W2035485568 countsByYear W20354855682017 @default.
• W2035485568 countsByYear W20354855682018 @default.
• W2035485568 countsByYear W20354855682022 @default.
• W2035485568 countsByYear W20354855682023 @default.
• W2035485568 crossrefType "journal-article" @default.
• W2035485568 hasAuthorship W2035485568A5018105714 @default.
• W2035485568 hasAuthorship W2035485568A5072182165 @default.
• W2035485568 hasAuthorship W2035485568A5083350316 @default.
• W2035485568 hasAuthorship W2035485568A5085248591 @default.
• W2035485568 hasBestOaLocation W20354855681 @default.
• W2035485568 hasConcept C101762097 @default.
• W2035485568 hasConcept C104317684 @default.
• W2035485568 hasConcept C134320426 @default.
• W2035485568 hasConcept C150194340 @default.
• W2035485568 hasConcept C153911025 @default.
• W2035485568 hasConcept C27153228 @default.
• W2035485568 hasConcept C2910353367 @default.
• W2035485568 hasConcept C29537977 @default.
• W2035485568 hasConcept C502942594 @default.
• W2035485568 hasConcept C54355233 @default.
• W2035485568 hasConcept C555283112 @default.
• W2035485568 hasConcept C83640560 @default.
• W2035485568 hasConcept C86339819 @default.
• W2035485568 hasConcept C86803240 @default.
• W2035485568 hasConceptScore W2035485568C101762097 @default.
• W2035485568 hasConceptScore W2035485568C104317684 @default.
• W2035485568 hasConceptScore W2035485568C134320426 @default.
• W2035485568 hasConceptScore W2035485568C150194340 @default.
• W2035485568 hasConceptScore W2035485568C153911025 @default.
• W2035485568 hasConceptScore W2035485568C27153228 @default.
• W2035485568 hasConceptScore W2035485568C2910353367 @default.
• W2035485568 hasConceptScore W2035485568C29537977 @default.
• W2035485568 hasConceptScore W2035485568C502942594 @default.
• W2035485568 hasConceptScore W2035485568C54355233 @default.
• W2035485568 hasConceptScore W2035485568C555283112 @default.
• W2035485568 hasConceptScore W2035485568C83640560 @default.

• next