Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035489344> ?p ?o ?g. }
- W2035489344 endingPage "499" @default.
- W2035489344 startingPage "491" @default.
- W2035489344 abstract "To assess the role of tumor necrosis factor- α (TNF- α) in modulating the process of cerebral ischemic injury, we identified TNF- α-producing cells and studied the time course of TNF- α expression. Immunoreactivity for TNF- α appeared in white matter of the mouse hippocampus as early as 1.5 h following a 30-min global ischemic insult. Double staining for TNF- α and glial fibrillary acidic protein (GFAP) suggested that the TNF- α-positive cells are most likely microglia, not astrocytes. TNF- α immunostaining decreased at 6 and 24 h but increased again at 3 days, when pyramidal neurons showed degeneration. Adjacent-section staining for microglia and double staining with GFAP suggested that TNF- α-positive cells in the pyramidal cell layer were microglia and those in the white matter were astrocytes. By 5 days TNF- α immunostaining disappeared from these glial cells, while a number of microglia were accumulated in the degenerated hippocampal pyramidal layer. Pyramidal neurons never expressed TNF- α immunoreactivity. Western blotting confirmed biphasic TNF- α expression. Our findings suggest that early production of TNF- α by microglia may activate a cytokine network in postischemic brain resulting in TNF- α synthesis by astrocytes." @default.
- W2035489344 created "2016-06-24" @default.
- W2035489344 creator A5000876487 @default.
- W2035489344 creator A5026854132 @default.
- W2035489344 creator A5040559233 @default.
- W2035489344 creator A5054251357 @default.
- W2035489344 creator A5086205857 @default.
- W2035489344 date "1997-05-01" @default.
- W2035489344 modified "2023-10-03" @default.
- W2035489344 title "Induction of Tumor Necrosis Factor-<i>α</i>in the Mouse Hippocampus following Transient Forebrain Ischemia" @default.
- W2035489344 cites W1496877897 @default.
- W2035489344 cites W1497131246 @default.
- W2035489344 cites W1568529372 @default.
- W2035489344 cites W1587762493 @default.
- W2035489344 cites W1967719961 @default.
- W2035489344 cites W1970197459 @default.
- W2035489344 cites W1975298116 @default.
- W2035489344 cites W1994426001 @default.
- W2035489344 cites W1999881215 @default.
- W2035489344 cites W2012066718 @default.
- W2035489344 cites W2013662783 @default.
- W2035489344 cites W2014461783 @default.
- W2035489344 cites W2023003439 @default.
- W2035489344 cites W2024906564 @default.
- W2035489344 cites W2025392129 @default.
- W2035489344 cites W2040957577 @default.
- W2035489344 cites W2041356020 @default.
- W2035489344 cites W2042393284 @default.
- W2035489344 cites W2053301460 @default.
- W2035489344 cites W2057829743 @default.
- W2035489344 cites W2058586534 @default.
- W2035489344 cites W2064329226 @default.
- W2035489344 cites W2069132198 @default.
- W2035489344 cites W2072628515 @default.
- W2035489344 cites W2076659607 @default.
- W2035489344 cites W2076735215 @default.
- W2035489344 cites W2082011784 @default.
- W2035489344 cites W2084883686 @default.
- W2035489344 cites W2089172549 @default.
- W2035489344 cites W2094166208 @default.
- W2035489344 cites W2100994529 @default.
- W2035489344 cites W2122175586 @default.
- W2035489344 cites W2135271960 @default.
- W2035489344 cites W2159746265 @default.
- W2035489344 cites W2164485496 @default.
- W2035489344 cites W2292619439 @default.
- W2035489344 cites W2418342481 @default.
- W2035489344 doi "https://doi.org/10.1097/00004647-199705000-00002" @default.
- W2035489344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9183286" @default.
- W2035489344 hasPublicationYear "1997" @default.
- W2035489344 type Work @default.
- W2035489344 sameAs 2035489344 @default.
- W2035489344 citedByCount "161" @default.
- W2035489344 countsByYear W20354893442012 @default.
- W2035489344 countsByYear W20354893442013 @default.
- W2035489344 countsByYear W20354893442014 @default.
- W2035489344 countsByYear W20354893442015 @default.
- W2035489344 countsByYear W20354893442016 @default.
- W2035489344 countsByYear W20354893442017 @default.
- W2035489344 countsByYear W20354893442018 @default.
- W2035489344 countsByYear W20354893442019 @default.
- W2035489344 countsByYear W20354893442021 @default.
- W2035489344 countsByYear W20354893442022 @default.
- W2035489344 crossrefType "journal-article" @default.
- W2035489344 hasAuthorship W2035489344A5000876487 @default.
- W2035489344 hasAuthorship W2035489344A5026854132 @default.
- W2035489344 hasAuthorship W2035489344A5040559233 @default.
- W2035489344 hasAuthorship W2035489344A5054251357 @default.
- W2035489344 hasAuthorship W2035489344A5086205857 @default.
- W2035489344 hasBestOaLocation W20354893441 @default.
- W2035489344 hasConcept C126322002 @default.
- W2035489344 hasConcept C134018914 @default.
- W2035489344 hasConcept C142724271 @default.
- W2035489344 hasConcept C148762608 @default.
- W2035489344 hasConcept C169760540 @default.
- W2035489344 hasConcept C17991360 @default.
- W2035489344 hasConcept C203014093 @default.
- W2035489344 hasConcept C204232928 @default.
- W2035489344 hasConcept C2776914184 @default.
- W2035489344 hasConcept C2777542381 @default.
- W2035489344 hasConcept C2779830541 @default.
- W2035489344 hasConcept C2780495277 @default.
- W2035489344 hasConcept C2780884517 @default.
- W2035489344 hasConcept C2781161787 @default.
- W2035489344 hasConcept C4224716 @default.
- W2035489344 hasConcept C529278444 @default.
- W2035489344 hasConcept C541997718 @default.
- W2035489344 hasConcept C71924100 @default.
- W2035489344 hasConcept C86803240 @default.
- W2035489344 hasConceptScore W2035489344C126322002 @default.
- W2035489344 hasConceptScore W2035489344C134018914 @default.
- W2035489344 hasConceptScore W2035489344C142724271 @default.
- W2035489344 hasConceptScore W2035489344C148762608 @default.
- W2035489344 hasConceptScore W2035489344C169760540 @default.
- W2035489344 hasConceptScore W2035489344C17991360 @default.
- W2035489344 hasConceptScore W2035489344C203014093 @default.
- W2035489344 hasConceptScore W2035489344C204232928 @default.
- W2035489344 hasConceptScore W2035489344C2776914184 @default.