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• W2035493003 abstract "Despite a century of scientific study and of socioeconomic advance classical rickets and osteomalacia are as apparent in England today as in the developing world. Forty-five patients with overt classical late rickets and osteomalacia presenting over a five-year period provided the basis for a study of age, sex and race distribution, symptoms and their onset, clinical signs, radiology and response to treatment. Results, together with measurements of plasma 250HD among newly arrived emigrants from Uganda, suggest that residence in England is a significant factor in the production of disease among Asian patients originating from East Africa. Biochemical abnormalities were quantitated. Fifty per cent of patients with overt disease were normocalcaemic. Serum alkaline phosphatase may be unequivocally normal in severe disease. Human requirement for oral 1,25(OH)2D3 when replacing outside sources of vitamin D was close to 7 ng/kg/day. 24,25(OH)2D3 was neither effective nor necessary for the apparent cure of osteomalacia. 1,25(OH)2D3 was no more than 10 to 40 times more effective than 25(OH)D3 on a weight basis. Both 1,25(OH)2D3 and 25(OH)D3 effectively increased renal tubular phosphate reabsorption. Serum phosphorus showed a highly significant biphasic response during long-term treatment, elevated levels being recorded during most of the period of bone remineralization (up to four months). The extent and frequency of a rise in serum alkaline phosphatase during treatment was quantitated." @default.
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• W2035493003 date "1980-03-01" @default.
• W2035493003 modified "2023-10-01" @default.
• W2035493003 title "5 Nutritional osteomalacia and late Rickets in Greater London, 1974–1979: Clinical and metabolic studies in 45 patients" @default.
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• W2035493003 doi "https://doi.org/10.1016/s0300-595x(80)80022-3" @default.
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