Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035505645> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2035505645 endingPage "1620" @default.
- W2035505645 startingPage "1615" @default.
- W2035505645 abstract "Female 55-day-old Sprague-Dawley rats were treated with a single intravenous dose of 7,12-dimethylbenzanthracene (DMBA), 2 mg/100g of body weight each. At 60 days of age, the rats were divided into four dietary groups (41–42 rats/group): I,5% corn oil diet fed ad libitum; II, 20% corn oil diet fed ad libitum; III,5% corn oil diet fed 12% less than group I; and IV, 20% corn oil diets fed 12% less than group II. The 5% and 20% corn oil diets were purified semisynthetic diets that were isonutrient on a caloric basis. All animals were housed individually in single cages; food consumption of each animal was computed daily throughout the study. Sixteen weeks after carcinogen treatment, mean numbers of mammary carcinomas per rat (±SE) in groups I, III, and IV were 4.1±0.6, 6.8±0.7, 3.0±0.3, and 4.1±0.5, respectively. Mean weight of mammary carcinomas per rat (g±SE) in groups I, II, III, and IV were 3.5 ± 0.7, 8.0 ± 1.3, 3.0± 1.1, and 4.6 ± 1.3, respectively. Mammary carcinoma number and weight were significantly (P<.01) increased in the animals fed the 20% corn oil diet ad libuitum when compared with those fed the 5% corn oil diet ad libitum; however, no significant differences in mammary tumor number or weight were observed between the animals fed a restricted, 20% corn oil diet and those fed a restricted, 5% corn oil diet. The study involving the animals fed the 12%-restricted diets was repeated (38– rats/group), with virtually indentical results, i.e., the mean number of mammary carcinomas per rat in the groups fed the restricted 5% fat and 20% fat diets at termination of the study was 3.1 ± 0.4 and 3.7 ± 0.3, respectively, and the mean weight (g) of mammary carcinomas per rat was 4.3 ± 1.2 and 4.0 ± 1.1, respectively (no significant differences). Thus, high levels of dietary fat can significantly enhance mammary carcinogenesis in female rats, but only in animals on an libitum feeding protocol. A slight restriction in amount consumed (12% less than ad libitum) abolished the mammary carcinogenic differential between a high-fat and a low-fat diet." @default.
- W2035505645 created "2016-06-24" @default.
- W2035505645 creator A5009703423 @default.
- W2035505645 creator A5032949363 @default.
- W2035505645 creator A5047661623 @default.
- W2035505645 creator A5076115391 @default.
- W2035505645 creator A5087834401 @default.
- W2035505645 date "1990-10-17" @default.
- W2035505645 modified "2023-09-25" @default.
- W2035505645 title "Enhancement of Mammary Carcinogenesis by High Levels of Dietary Fat: A Phenomenon Dependent on Ad Libitum Feeding" @default.
- W2035505645 doi "https://doi.org/10.1093/jnci/82.20.1615" @default.
- W2035505645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2136369" @default.
- W2035505645 hasPublicationYear "1990" @default.
- W2035505645 type Work @default.
- W2035505645 sameAs 2035505645 @default.
- W2035505645 citedByCount "56" @default.
- W2035505645 countsByYear W20355056452012 @default.
- W2035505645 countsByYear W20355056452013 @default.
- W2035505645 countsByYear W20355056452016 @default.
- W2035505645 countsByYear W20355056452021 @default.
- W2035505645 crossrefType "journal-article" @default.
- W2035505645 hasAuthorship W2035505645A5009703423 @default.
- W2035505645 hasAuthorship W2035505645A5032949363 @default.
- W2035505645 hasAuthorship W2035505645A5047661623 @default.
- W2035505645 hasAuthorship W2035505645A5076115391 @default.
- W2035505645 hasAuthorship W2035505645A5087834401 @default.
- W2035505645 hasConcept C114246631 @default.
- W2035505645 hasConcept C121608353 @default.
- W2035505645 hasConcept C126322002 @default.
- W2035505645 hasConcept C134018914 @default.
- W2035505645 hasConcept C140793950 @default.
- W2035505645 hasConcept C147583825 @default.
- W2035505645 hasConcept C185592680 @default.
- W2035505645 hasConcept C2776187077 @default.
- W2035505645 hasConcept C2777546739 @default.
- W2035505645 hasConcept C2778206080 @default.
- W2035505645 hasConcept C2778938436 @default.
- W2035505645 hasConcept C2994001847 @default.
- W2035505645 hasConcept C509243982 @default.
- W2035505645 hasConcept C530470458 @default.
- W2035505645 hasConcept C55493867 @default.
- W2035505645 hasConcept C555283112 @default.
- W2035505645 hasConcept C71924100 @default.
- W2035505645 hasConcept C86803240 @default.
- W2035505645 hasConceptScore W2035505645C114246631 @default.
- W2035505645 hasConceptScore W2035505645C121608353 @default.
- W2035505645 hasConceptScore W2035505645C126322002 @default.
- W2035505645 hasConceptScore W2035505645C134018914 @default.
- W2035505645 hasConceptScore W2035505645C140793950 @default.
- W2035505645 hasConceptScore W2035505645C147583825 @default.
- W2035505645 hasConceptScore W2035505645C185592680 @default.
- W2035505645 hasConceptScore W2035505645C2776187077 @default.
- W2035505645 hasConceptScore W2035505645C2777546739 @default.
- W2035505645 hasConceptScore W2035505645C2778206080 @default.
- W2035505645 hasConceptScore W2035505645C2778938436 @default.
- W2035505645 hasConceptScore W2035505645C2994001847 @default.
- W2035505645 hasConceptScore W2035505645C509243982 @default.
- W2035505645 hasConceptScore W2035505645C530470458 @default.
- W2035505645 hasConceptScore W2035505645C55493867 @default.
- W2035505645 hasConceptScore W2035505645C555283112 @default.
- W2035505645 hasConceptScore W2035505645C71924100 @default.
- W2035505645 hasConceptScore W2035505645C86803240 @default.
- W2035505645 hasIssue "20" @default.
- W2035505645 hasLocation W20355056451 @default.
- W2035505645 hasLocation W20355056452 @default.
- W2035505645 hasOpenAccess W2035505645 @default.
- W2035505645 hasPrimaryLocation W20355056451 @default.
- W2035505645 hasRelatedWork W1542208203 @default.
- W2035505645 hasRelatedWork W2013644072 @default.
- W2035505645 hasRelatedWork W2014314517 @default.
- W2035505645 hasRelatedWork W2015950242 @default.
- W2035505645 hasRelatedWork W2035505645 @default.
- W2035505645 hasRelatedWork W2067422477 @default.
- W2035505645 hasRelatedWork W2317594652 @default.
- W2035505645 hasRelatedWork W2417492584 @default.
- W2035505645 hasRelatedWork W2465742825 @default.
- W2035505645 hasRelatedWork W2527543325 @default.
- W2035505645 hasVolume "82" @default.
- W2035505645 isParatext "false" @default.
- W2035505645 isRetracted "false" @default.
- W2035505645 magId "2035505645" @default.
- W2035505645 workType "article" @default.