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• W2035518124 abstract "Abstract A single nucleotide polymorphism‐chip analysis of 98 cases of aggressive B‐cell lymphomas revealed a recurrent deletion at 19p13 in nine of the cases. Six further cases with deletions encompassing this region were found in array‐comparative genomic hybridization data of 295 aggressive B‐cell lymphomas from a previous study. Three cases even showed a homozygous deletion, suggesting a tumor suppressor gene in the deleted region. Two genes encoding members of the tumor necrosis factor superfamily (TNFSF) were located in the minimally deleted region, that is, TNFSF7 and TNFSF9 . As no mutations were found within the coding exons of the remaining alleles in the lymphomas with heterozygous deletions, we speculate that the deletions may mostly function through a haploinsufficiency mechanism. The cases with deletions encompassed both diffuse large B‐cell lymphomas and Burkitt lymphomas, and a deletion was also found in a Hodgkin lymphoma cell line. Thus, TNFSF7 and TNFSF9 deletions are recurrent genetic lesions in multiple types of human lymphomas." @default.
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• W2035518124 date "2012-01-31" @default.
• W2035518124 modified "2023-10-18" @default.
• W2035518124 title "Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas" @default.
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• W2035518124 doi "https://doi.org/10.1002/ijc.27416" @default.
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