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- W2035528400 endingPage "334" @default.
- W2035528400 startingPage "321" @default.
- W2035528400 abstract "Drug addiction is a public health and social burden. Presently, the most abused illicit substance is cannabis, fol- lowed by amphetamines, cocaine and opioids, with different prevalence in different countries. Several evidences support a role for oxidative stress in the toxicity induced by many drugs of abuse in different organs, such as the brain, heart, liver or kidneys. This leads to oxidation of important cellular macromolecules, and may culminate in cell dysfunction and death. In this review we describe the evidences for oxidative damage and depletion of antioxidants upon exposure to drugs of abuse, especially amphetamines, cocaine and opiates. We also discuss the sources of oxidative stress induced by drugs of abuse, including oxidative metabolism of drugs, oxidative metabolism of monoamines by monoamine oxidases or by auto-oxidation, mitochondrial dysfunction, excitotoxicity, microglial activation, inflammation, hyperthermia and the ef- fects of drug interactions. These consolidate oxidative stress as a relevant mechanism contributing for the cytotoxicity of drugs of abuse and for behavioral changes associated with drug addiction." @default.
- W2035528400 created "2016-06-24" @default.
- W2035528400 creator A5042245824 @default.
- W2035528400 creator A5043027619 @default.
- W2035528400 creator A5058867273 @default.
- W2035528400 date "2013-12-31" @default.
- W2035528400 modified "2023-10-16" @default.
- W2035528400 title "Oxidative Stress and Drugs of Abuse: An Update" @default.
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