Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035529547> ?p ?o ?g. }
- W2035529547 endingPage "e5149" @default.
- W2035529547 startingPage "e5149" @default.
- W2035529547 abstract "Pericyte-endothelial cell (EC) interactions are critical to both vascular development and vessel stability. We have previously shown that TGF-beta signaling between EC and mural cells participates in vessel stabilization in vitro. We therefore investigated the role of TGF-beta signaling in maintaining microvessel structure and function in the adult mouse retinal microvasculature. TGF-beta signaling was inhibited by systemic expression of soluble endoglin (sEng) and inhibition was demonstrated by reduced phospho-smad2 in the adult retina. Blockade of TGF-beta signaling led to increased vascular and neural cell apoptosis in the retina, which was associated with decreased retinal function, as measured by electroretinogram (ERG). Perfusion of the inner retinal vasculature was impaired and was accompanied by defective autoregulation and loss of capillary integrity. Fundus angiography and Evans blue permeability assay revealed a breakdown of the blood-retinal-barrier that was characterized by decreased association between the tight junction proteins zo-1 and occludin. Inhibition of TGF-beta signaling in cocultures of EC and 10T1/2 cells corroborated the in vivo findings, with impaired EC barrier function, dissociation of EC from 10T1/2 cells, and endothelial cell death, supporting the role of EC-mesenchymal interactions in TGF-beta signaling. These results implicate constitutive TGF-beta signaling in maintaining the integrity and function of the adult microvasculature and shed light on the potential role of TGF-beta signaling in vasoproliferative and vascular degenerative retinal diseases." @default.
- W2035529547 created "2016-06-24" @default.
- W2035529547 creator A5000073854 @default.
- W2035529547 creator A5005938951 @default.
- W2035529547 creator A5011712879 @default.
- W2035529547 creator A5024270531 @default.
- W2035529547 creator A5040670188 @default.
- W2035529547 creator A5068364686 @default.
- W2035529547 date "2009-04-02" @default.
- W2035529547 modified "2023-10-14" @default.
- W2035529547 title "TGF-β Is Required for Vascular Barrier Function, Endothelial Survival and Homeostasis of the Adult Microvasculature" @default.
- W2035529547 cites W1562397511 @default.
- W2035529547 cites W1893444436 @default.
- W2035529547 cites W1964513396 @default.
- W2035529547 cites W1964563841 @default.
- W2035529547 cites W1967534342 @default.
- W2035529547 cites W1968762000 @default.
- W2035529547 cites W1969937534 @default.
- W2035529547 cites W1976678902 @default.
- W2035529547 cites W1978999523 @default.
- W2035529547 cites W1990790396 @default.
- W2035529547 cites W1994794221 @default.
- W2035529547 cites W1996427377 @default.
- W2035529547 cites W1997693327 @default.
- W2035529547 cites W1999315076 @default.
- W2035529547 cites W2002606648 @default.
- W2035529547 cites W2002621910 @default.
- W2035529547 cites W2004883460 @default.
- W2035529547 cites W2009673528 @default.
- W2035529547 cites W2017704148 @default.
- W2035529547 cites W2018778283 @default.
- W2035529547 cites W2032763419 @default.
- W2035529547 cites W2037111838 @default.
- W2035529547 cites W2039787319 @default.
- W2035529547 cites W2040583312 @default.
- W2035529547 cites W2068965405 @default.
- W2035529547 cites W2076503648 @default.
- W2035529547 cites W2078039829 @default.
- W2035529547 cites W2078835518 @default.
- W2035529547 cites W2082402917 @default.
- W2035529547 cites W2092671785 @default.
- W2035529547 cites W2100976582 @default.
- W2035529547 cites W2105632053 @default.
- W2035529547 cites W2118283324 @default.
- W2035529547 cites W2125302698 @default.
- W2035529547 cites W2127776747 @default.
- W2035529547 cites W2131005245 @default.
- W2035529547 cites W2137080888 @default.
- W2035529547 cites W2141231908 @default.
- W2035529547 cites W2152574565 @default.
- W2035529547 cites W2156606731 @default.
- W2035529547 cites W2159727837 @default.
- W2035529547 cites W2163220652 @default.
- W2035529547 cites W2416921080 @default.
- W2035529547 cites W2473770997 @default.
- W2035529547 cites W2770216137 @default.
- W2035529547 cites W4235369040 @default.
- W2035529547 doi "https://doi.org/10.1371/journal.pone.0005149" @default.
- W2035529547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2659748" @default.
- W2035529547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19340291" @default.
- W2035529547 hasPublicationYear "2009" @default.
- W2035529547 type Work @default.
- W2035529547 sameAs 2035529547 @default.
- W2035529547 citedByCount "178" @default.
- W2035529547 countsByYear W20355295472012 @default.
- W2035529547 countsByYear W20355295472013 @default.
- W2035529547 countsByYear W20355295472014 @default.
- W2035529547 countsByYear W20355295472015 @default.
- W2035529547 countsByYear W20355295472016 @default.
- W2035529547 countsByYear W20355295472017 @default.
- W2035529547 countsByYear W20355295472018 @default.
- W2035529547 countsByYear W20355295472019 @default.
- W2035529547 countsByYear W20355295472020 @default.
- W2035529547 countsByYear W20355295472021 @default.
- W2035529547 countsByYear W20355295472022 @default.
- W2035529547 countsByYear W20355295472023 @default.
- W2035529547 crossrefType "journal-article" @default.
- W2035529547 hasAuthorship W2035529547A5000073854 @default.
- W2035529547 hasAuthorship W2035529547A5005938951 @default.
- W2035529547 hasAuthorship W2035529547A5011712879 @default.
- W2035529547 hasAuthorship W2035529547A5024270531 @default.
- W2035529547 hasAuthorship W2035529547A5040670188 @default.
- W2035529547 hasAuthorship W2035529547A5068364686 @default.
- W2035529547 hasBestOaLocation W20355295471 @default.
- W2035529547 hasConcept C111758988 @default.
- W2035529547 hasConcept C113045295 @default.
- W2035529547 hasConcept C123012128 @default.
- W2035529547 hasConcept C134018914 @default.
- W2035529547 hasConcept C169760540 @default.
- W2035529547 hasConcept C177779419 @default.
- W2035529547 hasConcept C202751555 @default.
- W2035529547 hasConcept C2775962179 @default.
- W2035529547 hasConcept C2777093970 @default.
- W2035529547 hasConcept C2778229498 @default.
- W2035529547 hasConcept C2778371105 @default.
- W2035529547 hasConcept C2779829184 @default.
- W2035529547 hasConcept C2780427682 @default.
- W2035529547 hasConcept C2780827179 @default.