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- W2035539934 abstract "A model is proposed for immunological high zone- and self-tolerance that is based on the concept of overstimulation of replication: It is demonstrated that if proliferation is hindered by delayed response to nutritional deficiency, then under competitive conditions slower proliferation can become a survival advantage. This offers a resolution of the paradox that self-antigens promote both positive and negative selection in the development of lymphocytes. It also suggests that maintaining nutrition and caloric intake at a minimal level can prolong the survival of cancer patients if the cancer cells replicate more rapidly than healthy ones." @default.
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- W2035539934 date "2001-06-01" @default.
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- W2035539934 title "Slow Proliferation as a Survival Advantage: an Attempt to Resolve a Paradox" @default.
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- W2035539934 doi "https://doi.org/10.1006/jtbi.2001.2308" @default.
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