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- W2035548590 abstract "Photon attenuation in small animal nuclear medicine scans can be significant when using isotopes that emit lower energy photons such as iodine-125. We have developed a method to use microCT data to perform attenuation corrected small animal single-photon emission computed tomography (SPECT). A microCT calibration phantom was first imaged, and the resulting calibration curve was used to convert microCT image values to linear attenuation coefficient values that were then used in an iterative SPECT reconstruction algorithm. This method was applied to reconstruct a SPECT image of a uniform phantom filled with 125I-NaI. Without attenuation correction, the image suffered a 30% decrease in intensity in the center of the image, which was removed with the addition of attenuation correction. This reduced the relative standard deviation in the region of interest from 10% to 6%." @default.
- W2035548590 created "2016-06-24" @default.
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- W2035548590 date "2005-08-22" @default.
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- W2035548590 title "Attenuation correction for small animal SPECT imaging using x-ray CT data" @default.
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- W2035548590 doi "https://doi.org/10.1118/1.1984347" @default.
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