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- W2035551436 abstract "Neighboring-group participation in the reaction catalyzed by purine nucleoside phosphorylase involves a compression mode between the 5′- and 4′-ribosyl oxygens, facilitated by His257. The His257Gly mutant opens a space in the catalytic site. Hydrophobic 5′-substituted Immucillins are transition-state analogue inhibitors of this mutant enzyme. Dissociation constants as low as 2 pM are achieved, with Km/Kd as high as 400,000,000." @default.
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- W2035551436 date "2008-11-01" @default.
- W2035551436 modified "2023-09-23" @default.
- W2035551436 title "Immucillins in custom catalytic-site cavities" @default.
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- W2035551436 doi "https://doi.org/10.1016/j.bmcl.2008.08.047" @default.
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