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• W2035553618 startingPage "465" @default.
• W2035553618 abstract "The human gastrointestinal tract consists of a highly complex ecosystem of aerobic and anaerobic microorganisms that plays a significant role in the metabolism of nutrients as well as drugs. In the colon, bacteria ferment various types of substrates that are not susceptible to digestion in the small intestine. This arouses interest in specific drugs, drug delivery systems, and prodrugs that escape small bowel digestion, arrive intact, and are absorbed or degraded in the large bowel. For the past forty years, experience has been gained with the azo prodrug of 5-amino salicylic acid, salazopyrine, which is cleaved by colonic bacteria to its parent drug. Some laxative drugs were also reported to degrade into active metabolites in the colon. Lately equally interesting and more sophisticated microbial controlled delivery systems, have been developed based on similar principles." @default.
• W2035553618 created "2016-06-24" @default.
• W2035553618 creator A5043058484 @default.
• W2035553618 date "1990-08-01" @default.
• W2035553618 modified "2023-10-17" @default.
• W2035553618 title "Microbially controlled drug delivery to the colon" @default.
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• W2035553618 doi "https://doi.org/10.1002/bdd.2510110602" @default.
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