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- W2035562017 abstract "Lanthanides represent a group of very important but challenging analytes for biosensor development. These 15 elements are very similar in their chemical properties. So far, limited success has been realized using the rational ligand design approach. My laboratory has successfully accomplished the task of carrying out combinatorial selection to isolate lanthanide-dependent RNA-cleaving DNAzymes. We report two new DNAzymes, each discovered in a different selection condition and both are highly specific to lanthanides. When both DNAzymes are used together, it is possible to identify the last few heavy lanthanides. Upon introducing a phosphorothioate modification, one of the abovementioned DNAzymes becomes highly active with many toxic heavy metals. With the selection of more DNAzymes with different activity patterns cross the lanthanide series, a sensor array might be produced for identifying each ion. This article is a minireview of the current developments on this topic and some of the historical aspects. It reflects the main content of the Fred Beamish Award presentation delivered at the 2014 Canadian Society for Chemistry Conference in Vancouver. Future directions in this area are also discussed." @default.
- W2035562017 created "2016-06-24" @default.
- W2035562017 creator A5087037080 @default.
- W2035562017 date "2015-03-01" @default.
- W2035562017 modified "2023-09-27" @default.
- W2035562017 title "Lanthanide-dependent RNA-cleaving DNAzymes as metal biosensors" @default.
- W2035562017 cites W1581594845 @default.
- W2035562017 cites W1964261732 @default.
- W2035562017 cites W1967665136 @default.
- W2035562017 cites W1977709085 @default.
- W2035562017 cites W1977980497 @default.
- W2035562017 cites W1978059664 @default.
- W2035562017 cites W1980411311 @default.
- W2035562017 cites W1983825093 @default.
- W2035562017 cites W1987565198 @default.
- W2035562017 cites W1987821867 @default.
- W2035562017 cites W1987911559 @default.
- W2035562017 cites W1990535998 @default.
- W2035562017 cites W1996497147 @default.
- W2035562017 cites W1997111120 @default.
- W2035562017 cites W2000914047 @default.
- W2035562017 cites W2002661845 @default.
- W2035562017 cites W2007524989 @default.
- W2035562017 cites W2009853120 @default.
- W2035562017 cites W2010419892 @default.
- W2035562017 cites W2010456221 @default.
- W2035562017 cites W2012108057 @default.
- W2035562017 cites W2018124164 @default.
- W2035562017 cites W2018691490 @default.
- W2035562017 cites W2018882335 @default.
- W2035562017 cites W2026260247 @default.
- W2035562017 cites W2026821104 @default.
- W2035562017 cites W2030936891 @default.
- W2035562017 cites W2030973999 @default.
- W2035562017 cites W2031610430 @default.
- W2035562017 cites W2032804919 @default.
- W2035562017 cites W2035603740 @default.
- W2035562017 cites W2036821913 @default.
- W2035562017 cites W2039102143 @default.
- W2035562017 cites W2041857964 @default.
- W2035562017 cites W2044191148 @default.
- W2035562017 cites W2044510009 @default.
- W2035562017 cites W2055457399 @default.
- W2035562017 cites W2056594839 @default.
- W2035562017 cites W2058110112 @default.
- W2035562017 cites W2069688986 @default.
- W2035562017 cites W2071597330 @default.
- W2035562017 cites W2073387419 @default.
- W2035562017 cites W2074711360 @default.
- W2035562017 cites W2077716320 @default.
- W2035562017 cites W2078820160 @default.
- W2035562017 cites W2083733102 @default.
- W2035562017 cites W2087770263 @default.
- W2035562017 cites W2090233918 @default.
- W2035562017 cites W2095372525 @default.
- W2035562017 cites W2095469093 @default.
- W2035562017 cites W2096847256 @default.
- W2035562017 cites W2101290186 @default.
- W2035562017 cites W2105915844 @default.
- W2035562017 cites W2106462936 @default.
- W2035562017 cites W2111833731 @default.
- W2035562017 cites W2114513515 @default.
- W2035562017 cites W2120434145 @default.
- W2035562017 cites W2122934240 @default.
- W2035562017 cites W2137695857 @default.
- W2035562017 cites W2138613437 @default.
- W2035562017 cites W2140811054 @default.
- W2035562017 cites W2142408722 @default.
- W2035562017 cites W2147431408 @default.
- W2035562017 cites W2148838855 @default.
- W2035562017 cites W2148927448 @default.
- W2035562017 cites W2158011953 @default.
- W2035562017 cites W2168633094 @default.
- W2035562017 cites W2169715159 @default.
- W2035562017 cites W2172098894 @default.
- W2035562017 cites W2319621092 @default.
- W2035562017 cites W2319883821 @default.
- W2035562017 cites W2333427263 @default.
- W2035562017 cites W2334332185 @default.
- W2035562017 cites W2335093845 @default.
- W2035562017 cites W2950692198 @default.
- W2035562017 cites W4238002074 @default.
- W2035562017 doi "https://doi.org/10.1139/cjc-2014-0465" @default.
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