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• W2035563321 abstract "Since enteric microbial composition is a distinctive and stable individual trait, microbial heterogeneity may confer lifelong, non-genetic differences between individuals. Here we report that C57BL/6 mice bearing restricted flora microbiota, a distinct but diverse resident enteric microbial community, are numerically and functionally deficient in marginal zone (MZ) B cells. Surprisingly, MZ B-cell levels are minimally affected by germ-free conditions or null mutations of various TLR signaling molecules. In contrast, MZ B-cell depletion is exquisitely dependent on cytolytic CD8+ T cells, and includes targeting of a cross-reactive microbial/endogenous MHC class 1B antigen. Thus, members of certain enteric microbial communities link with CD8+ T cells as a previously unappreciated mechanism that shapes innate immunity dependent on innate-like B cells." @default.
• W2035563321 created "2016-06-24" @default.
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• W2035563321 date "2008-11-13" @default.
• W2035563321 modified "2023-10-18" @default.
• W2035563321 title "Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells" @default.
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• W2035563321 doi "https://doi.org/10.1002/eji.200838432" @default.
• W2035563321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2734463" @default.
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