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- W2035563566 abstract "Preconditioning (PC) prevents ventricular fibrillation (VF) in the rat heart. We sought to determine whether this protective effect might: (1) apply to the pig heart, (2) be related to modifications of electrophysiologic parameters. Fortyeight anesthetized pigs underwent 40 min of LAD coronary artery occlusion (CO) followed by 2 hours of reperfusion (R). Prior to this, PC hearts received 10 min of CO and 10 min of R. Area at risk and infarct size were measured by injection of blue dye and triphenyltetrazolium staining, respectively. Duration of subepicardial monophasic action potential (MAPD) and VF threshold were measured at different time points of the experiment. As expected, infarct size was significantly reduced in PC hearts, averaging 6 ± 4%* of the risk region versus 28 ± 4% in controls (* p < 0.01). But, incidence of VF was not reduced in the PC group: 69% vs 63% in the control group (p = NSI. Furthermore, time to VF during the 40 minute CO was significantly shorter in PC than in control hearts: 7 ± 2 min* vs 18 ± 2 min (* p < 0.01). This was associated with a significantly lower VF threshold and shortening of MAPD in PC hearts at the onset of the sustained CO. At 3 min of ischemia, VF threshold averaged 2.3 ± 1.7 mA (* in PC vs 4.1 ± 2.4 mA in controls (* p < 0.01 vs control). MAPD averaged 197 ± 4 ms* in PC hearts versus 214 ± 4 ms in controls (* p < 0.05). This suggests that preconditioning does not prevent but accelerates ventricular fibrillation in pig hearts via a decrease of the fibrillation threshold and a shortening of monophasic action potential during the first minutes of the sustained ischemia." @default.
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- W2035563566 date "1995-02-01" @default.
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- W2035563566 title "706-4 Preconditioning Shortens Action Potential Duration and Lowers Ventricular Fibrillation Threshold in Pig Hearts" @default.
- W2035563566 doi "https://doi.org/10.1016/0735-1097(95)91635-b" @default.
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