FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035565560> ?p ?o ?g. }

• W2035565560 endingPage "1017" @default.
• W2035565560 startingPage "1007" @default.
• W2035565560 abstract "Background: Understanding the molecular features of bone repair and osseointegration may aid in the development of therapeutics to improve implant outcomes. The purpose of this investigation is to determine the gene expression dynamics during alveolar bone repair and implant osseointegration. Methods: An implant osseointegration preclinical animal model was used whereby maxillary defects were created at the time of oral implant placement, while a tooth extraction socket healing model was established on the contralateral side of each animal. The surrounding tissues in the zone of the healing defects were harvested during regeneration for temporal evaluation using histology, immunohistochemistry, laser capture microdissection, and quantitative reverse transcription–polymerase chain reaction for the identification of a panel of 17 putative genes associated with wound repair. Results: In both models, three distinct expression patterns were displayed: 1) genes that are slowly increased during the healing process, such as bone morphogenetic protein 4, runt‐related transcription factor 2, and osteocalcin; 2) genes that are upregulated at the early stage of healing and then downregulated at later stages, such as interleukin and chemokine (C‐X‐C motif) ligands 2 and 5; and 3) genes that are constitutively expressed over time, such as scleraxis. Although some similarities between osseointegration and tooth extraction socket were seen, distinct features developed and triggered a characteristic coordinated expression and orchestration of transcription factors, growth factors, extracellular matrix molecules, and chemokines. Conclusions: Characterization of these events contributes to a better understanding of cooperative molecular dynamics in alveolar bone healing, and highlights potential pathways that could be further explored for the enhancement of osseous regenerative strategies." @default.
• W2035565560 created "2016-06-24" @default.
• W2035565560 creator A5017082027 @default.
• W2035565560 creator A5027121293 @default.
• W2035565560 creator A5044774272 @default.
• W2035565560 creator A5046679612 @default.
• W2035565560 creator A5067718927 @default.
• W2035565560 creator A5081643464 @default.
• W2035565560 date "2011-07-01" @default.
• W2035565560 modified "2023-10-08" @default.
• W2035565560 title "Gene Expression Dynamics During Bone Healing and Osseointegration" @default.
• W2035565560 cites W1520230219 @default.
• W2035565560 cites W1524578276 @default.
• W2035565560 cites W1947096230 @default.
• W2035565560 cites W1967391290 @default.
• W2035565560 cites W1968786278 @default.
• W2035565560 cites W1971426308 @default.
• W2035565560 cites W1971665864 @default.
• W2035565560 cites W1972344669 @default.
• W2035565560 cites W1979007375 @default.
• W2035565560 cites W1990660545 @default.
• W2035565560 cites W1990948383 @default.
• W2035565560 cites W1992662283 @default.
• W2035565560 cites W1994913938 @default.
• W2035565560 cites W2011828467 @default.
• W2035565560 cites W2015310514 @default.
• W2035565560 cites W2018290082 @default.
• W2035565560 cites W2027989922 @default.
• W2035565560 cites W2036269938 @default.
• W2035565560 cites W2048492086 @default.
• W2035565560 cites W2055746941 @default.
• W2035565560 cites W2058924496 @default.
• W2035565560 cites W2060084953 @default.
• W2035565560 cites W2065626035 @default.
• W2035565560 cites W2071333416 @default.
• W2035565560 cites W2071984766 @default.
• W2035565560 cites W2073260359 @default.
• W2035565560 cites W2078499568 @default.
• W2035565560 cites W2082858140 @default.
• W2035565560 cites W2086493668 @default.
• W2035565560 cites W2086739940 @default.
• W2035565560 cites W2087913054 @default.
• W2035565560 cites W2100742385 @default.
• W2035565560 cites W2101087657 @default.
• W2035565560 cites W2103198077 @default.
• W2035565560 cites W2104048619 @default.
• W2035565560 cites W2105913013 @default.
• W2035565560 cites W2110583027 @default.
• W2035565560 cites W2117492368 @default.
• W2035565560 cites W2126645496 @default.
• W2035565560 cites W2132551393 @default.
• W2035565560 cites W2136823415 @default.
• W2035565560 cites W2140211083 @default.
• W2035565560 cites W2140919529 @default.
• W2035565560 cites W2155928111 @default.
• W2035565560 cites W2159585093 @default.
• W2035565560 cites W2172194489 @default.
• W2035565560 cites W2353578725 @default.
• W2035565560 doi "https://doi.org/10.1902/jop.2010.100577" @default.
• W2035565560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3399909" @default.
• W2035565560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21142982" @default.
• W2035565560 hasPublicationYear "2011" @default.
• W2035565560 type Work @default.
• W2035565560 sameAs 2035565560 @default.
• W2035565560 citedByCount "75" @default.
• W2035565560 countsByYear W20355655602012 @default.
• W2035565560 countsByYear W20355655602013 @default.
• W2035565560 countsByYear W20355655602014 @default.
• W2035565560 countsByYear W20355655602015 @default.
• W2035565560 countsByYear W20355655602016 @default.
• W2035565560 countsByYear W20355655602017 @default.
• W2035565560 countsByYear W20355655602018 @default.
• W2035565560 countsByYear W20355655602019 @default.
• W2035565560 countsByYear W20355655602020 @default.
• W2035565560 countsByYear W20355655602021 @default.
• W2035565560 countsByYear W20355655602022 @default.
• W2035565560 countsByYear W20355655602023 @default.
• W2035565560 crossrefType "journal-article" @default.
• W2035565560 hasAuthorship W2035565560A5017082027 @default.
• W2035565560 hasAuthorship W2035565560A5027121293 @default.
• W2035565560 hasAuthorship W2035565560A5044774272 @default.
• W2035565560 hasAuthorship W2035565560A5046679612 @default.
• W2035565560 hasAuthorship W2035565560A5067718927 @default.
• W2035565560 hasAuthorship W2035565560A5081643464 @default.
• W2035565560 hasBestOaLocation W20355655601 @default.
• W2035565560 hasConcept C101414908 @default.
• W2035565560 hasConcept C105702510 @default.
• W2035565560 hasConcept C141071460 @default.
• W2035565560 hasConcept C151279780 @default.
• W2035565560 hasConcept C189165786 @default.
• W2035565560 hasConcept C199343813 @default.
• W2035565560 hasConcept C2780269544 @default.
• W2035565560 hasConcept C2781411149 @default.
• W2035565560 hasConcept C54355233 @default.
• W2035565560 hasConcept C71924100 @default.
• W2035565560 hasConcept C8337478 @default.
• W2035565560 hasConcept C86803240 @default.
• W2035565560 hasConcept C95444343 @default.

• next