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- W2035581654 abstract "HIV-1 replicates in immune cells that normally respond to incoming viruses and induce antiviral immune responses. Under this constant surveillance, how HIV-1 interacts with the host to escape immune control and causes immunopathology is still being untangled. Recently, a series of HIV-1 interactions with innate sensors of viruses expressed by immune target cells have been identified. Here, we review the HIV-1 factors that escape, engage and regulate these innate immune sensors. We discuss the general principles of these interactions as well as the remarkable cell-type specificity of the regulatory mechanisms and their resulting immune responses. Innate sensors directly intersect viral replication with immunity, and understanding their triggering, or lack thereof, improves our ability to design immune interventions." @default.
- W2035581654 created "2016-06-24" @default.
- W2035581654 creator A5021258372 @default.
- W2035581654 creator A5077609252 @default.
- W2035581654 date "2015-04-01" @default.
- W2035581654 modified "2023-09-26" @default.
- W2035581654 title "Viral and cellular mechanisms of the innate immune sensing of HIV" @default.
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- W2035581654 doi "https://doi.org/10.1016/j.coviro.2015.01.013" @default.
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