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- W2035582064 abstract "Type 1 diabetes (T1D) results from progressive immune cell-mediated destruction of pancreatic β cells. As immune cells migrate into the islets, they pass through the extracellular matrix (ECM). This ECM is composed of different macromolecules localized to different compartments within and surrounding islets; however, the involvement of this ECM in the development of human T1D is not well understood. Here, we summarize our recent findings from human and mouse studies illustrating how specific components of the islet ECM that constitute basement membranes and interstitial matrix of the islets, and surprisingly, the intracellular composition of islet β cells themselves, are significantly altered during the pathogenesis of T1D. Our focus is on the ECM molecules laminins, collagens, heparan sulfate/heparan sulfate proteoglycans, and hyaluronan, as well as on the enzymes that degrade these ECM components. We propose that islet and lymphoid tissue ECM composition and organization are critical to promoting immune cell activation, islet invasion, and destruction of islet β cells in T1D." @default.
- W2035582064 created "2016-06-24" @default.
- W2035582064 creator A5004378999 @default.
- W2035582064 creator A5031189214 @default.
- W2035582064 creator A5031719922 @default.
- W2035582064 creator A5035268339 @default.
- W2035582064 creator A5062759373 @default.
- W2035582064 creator A5068646165 @default.
- W2035582064 date "2014-10-26" @default.
- W2035582064 modified "2023-10-17" @default.
- W2035582064 title "Extracellular Matrix Components in the Pathogenesis of Type 1 Diabetes" @default.
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