Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035582563> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2035582563 endingPage "364" @default.
- W2035582563 startingPage "355" @default.
- W2035582563 abstract "To study the behaviour of polymeric materials under in-vivo conditions, degradable macromolecular micelles based on amphiphilic block copolymers of poly(β-malic acid) as hydrophilic units and poly(β-malic acid alkyl esters) as hydrophobic blocks are studied. First three β-substituted β-lactones, benzyl malolactonate, butyl malolactonate, and butyl 3-methylmalolactonate were prepared, starting from aspartic acid. A prepolymer based on benzyl malate units was synthesized by anionic ring-opening polymerization of benzyl malolactonate. Then the carboxylic end groups of this prepolymer were used as initiator for the polymerization of the second lactone, e. g. butyl malolactonate or butyl 3-methylmalolactonate. The prepolymer and block copolymers have been characterized by 1H NMR and size exclusion chromatography (SEC). Degradable macromolecular micelles were prepared from the block copolymers by two different methods and characterized by dynamic light scattering and fluorescence measurements using pyrene as a fluorescence probe. It was shown that these amphiphilic degradable copolymers form stable micelles under physiological conditions (10–2 M phosphate buffered solution, PBS, pH 7.4 with 0.15 M NaCl). Moreover, it was displayed that the characteristics of these macromolecular micelles, especially the critical micellar concentration (cmc), are depending on the chain length of both blocks and on the chemical structure of the hydrophobic block. A very important conclusion of this study is, that micelle formation is dependent on the pH of the medium. Therefore, besides the fact that such micelles are potentially degradable into non-toxic low molecular weight molecules, their properties and stability were proven to be pH-dependent. This property can lead development of an “intelligent” drug carrier able to release the entrapped biologically active molecule depending on the pH values." @default.
- W2035582563 created "2016-06-24" @default.
- W2035582563 creator A5015097923 @default.
- W2035582563 creator A5021216695 @default.
- W2035582563 creator A5040666669 @default.
- W2035582563 creator A5059170988 @default.
- W2035582563 creator A5074816468 @default.
- W2035582563 date "2000-02-01" @default.
- W2035582563 modified "2023-09-30" @default.
- W2035582563 title "New macromolecular micelles based on degradable amphiphilic block copolymers of malic acid and malic acid ester" @default.
- W2035582563 doi "https://doi.org/10.1002/(sici)1521-3935(20000201)201:3<355::aid-macp355>3.0.co;2-9" @default.
- W2035582563 hasPublicationYear "2000" @default.
- W2035582563 type Work @default.
- W2035582563 sameAs 2035582563 @default.
- W2035582563 citedByCount "38" @default.
- W2035582563 countsByYear W20355825632012 @default.
- W2035582563 countsByYear W20355825632013 @default.
- W2035582563 countsByYear W20355825632014 @default.
- W2035582563 countsByYear W20355825632015 @default.
- W2035582563 countsByYear W20355825632016 @default.
- W2035582563 countsByYear W20355825632018 @default.
- W2035582563 countsByYear W20355825632020 @default.
- W2035582563 countsByYear W20355825632022 @default.
- W2035582563 crossrefType "journal-article" @default.
- W2035582563 hasAuthorship W2035582563A5015097923 @default.
- W2035582563 hasAuthorship W2035582563A5021216695 @default.
- W2035582563 hasAuthorship W2035582563A5040666669 @default.
- W2035582563 hasAuthorship W2035582563A5059170988 @default.
- W2035582563 hasAuthorship W2035582563A5074816468 @default.
- W2035582563 hasConcept C11268172 @default.
- W2035582563 hasConcept C15920480 @default.
- W2035582563 hasConcept C178790620 @default.
- W2035582563 hasConcept C184651966 @default.
- W2035582563 hasConcept C185592680 @default.
- W2035582563 hasConcept C188027245 @default.
- W2035582563 hasConcept C204389451 @default.
- W2035582563 hasConcept C2779032678 @default.
- W2035582563 hasConcept C2779498867 @default.
- W2035582563 hasConcept C2779578285 @default.
- W2035582563 hasConcept C2780968799 @default.
- W2035582563 hasConcept C44228677 @default.
- W2035582563 hasConcept C521977710 @default.
- W2035582563 hasConcept C55493867 @default.
- W2035582563 hasConcept C64237528 @default.
- W2035582563 hasConcept C67407626 @default.
- W2035582563 hasConceptScore W2035582563C11268172 @default.
- W2035582563 hasConceptScore W2035582563C15920480 @default.
- W2035582563 hasConceptScore W2035582563C178790620 @default.
- W2035582563 hasConceptScore W2035582563C184651966 @default.
- W2035582563 hasConceptScore W2035582563C185592680 @default.
- W2035582563 hasConceptScore W2035582563C188027245 @default.
- W2035582563 hasConceptScore W2035582563C204389451 @default.
- W2035582563 hasConceptScore W2035582563C2779032678 @default.
- W2035582563 hasConceptScore W2035582563C2779498867 @default.
- W2035582563 hasConceptScore W2035582563C2779578285 @default.
- W2035582563 hasConceptScore W2035582563C2780968799 @default.
- W2035582563 hasConceptScore W2035582563C44228677 @default.
- W2035582563 hasConceptScore W2035582563C521977710 @default.
- W2035582563 hasConceptScore W2035582563C55493867 @default.
- W2035582563 hasConceptScore W2035582563C64237528 @default.
- W2035582563 hasConceptScore W2035582563C67407626 @default.
- W2035582563 hasIssue "3" @default.
- W2035582563 hasLocation W20355825631 @default.
- W2035582563 hasOpenAccess W2035582563 @default.
- W2035582563 hasPrimaryLocation W20355825631 @default.
- W2035582563 hasRelatedWork W1984149351 @default.
- W2035582563 hasRelatedWork W2005954716 @default.
- W2035582563 hasRelatedWork W2024674786 @default.
- W2035582563 hasRelatedWork W2061411460 @default.
- W2035582563 hasRelatedWork W2116888576 @default.
- W2035582563 hasRelatedWork W2358834348 @default.
- W2035582563 hasRelatedWork W2751315806 @default.
- W2035582563 hasRelatedWork W2945139002 @default.
- W2035582563 hasRelatedWork W3161161857 @default.
- W2035582563 hasRelatedWork W3122516261 @default.
- W2035582563 hasVolume "201" @default.
- W2035582563 isParatext "false" @default.
- W2035582563 isRetracted "false" @default.
- W2035582563 magId "2035582563" @default.
- W2035582563 workType "article" @default.