FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035584793> ?p ?o ?g. }

• W2035584793 abstract "Synapsin I, a prominent phosphoprotein in nerve terminals, is proposed to modulate exocytosis by interaction with the cytoplasmic surface of small synaptic vesicles and cytoskeletal elements in a phosphorylation-dependent manner. Tetanus toxin (TeTx), a potent inhibitor of neurotransmitter release, attenuated the depolarization-stimulated increase in synapsin I phosphorylation in rat cortical particles and in synaptosomes. TeTx also markedly decreased the translocation of synapsin I from the small synaptic vesicles and the cytoskeleton into the cytosol, on depolarization of synaptosomes. The effect of TeTx on synapsin I phosphorylation was both time and TeTx concentration dependent and required active toxin. One- and two-dimensional peptide maps of synapsin I with V8 proteinase and trypsin, respectively, showed no differences in the relative phosphorylation of peptides for the control and TeTx-treated synaptosomes, suggesting that both the calmodulin- and the cyclic AMP-dependent kinases that label this protein are equally affected. Phosphorylation of synapsin IIb and the B-50 protein (GAP43), a known substrate of protein kinase C, was also inhibited by TeTx. TeTx affected only a limited number of phosphoproteins and the calcium-dependent decrease in dephosphin phosphorylation remained unaffected. In vitro phosphorylation of proteins in lysed synaptosomes was not influenced by prior TeTx treatment of the intact synaptosomes or by the addition of TeTx to lysates, suggesting that the effect of TeTx on protein phosphorylation was indirect. Our data demonstrate that TeTx inhibits neurotransmitter release, the phosphorylation of a select group of phosphoproteins in nerve terminals, and the translocation of synapsin I. These findings contribute to our understanding of the basic mechanism of TeTx action." @default.
• W2035584793 created "2016-06-24" @default.
• W2035584793 creator A5023516295 @default.
• W2035584793 creator A5070033763 @default.
• W2035584793 creator A5071392053 @default.
• W2035584793 creator A5071694712 @default.
• W2035584793 creator A5082311017 @default.
• W2035584793 creator A5085484250 @default.
• W2035584793 date "1992-10-01" @default.
• W2035584793 modified "2023-09-26" @default.
• W2035584793 title "Tetanus Toxin Inhibits Depolarization-Stimulated Protein Phosphorylation in Rat Cortical Synaptosomes: Effect on Synapsin I Phosphorylation and Translocation" @default.
• W2035584793 cites W1451723869 @default.
• W2035584793 cites W1483698898 @default.
• W2035584793 cites W1489351324 @default.
• W2035584793 cites W1527438907 @default.
• W2035584793 cites W1679417272 @default.
• W2035584793 cites W1966379399 @default.
• W2035584793 cites W1977478068 @default.
• W2035584793 cites W1977758375 @default.
• W2035584793 cites W1982807202 @default.
• W2035584793 cites W1984278998 @default.
• W2035584793 cites W1990375898 @default.
• W2035584793 cites W1994283509 @default.
• W2035584793 cites W1997778299 @default.
• W2035584793 cites W2031423487 @default.
• W2035584793 cites W2034994589 @default.
• W2035584793 cites W2041255103 @default.
• W2035584793 cites W2045412334 @default.
• W2035584793 cites W2046990869 @default.
• W2035584793 cites W2047143441 @default.
• W2035584793 cites W2059224296 @default.
• W2035584793 cites W2063489769 @default.
• W2035584793 cites W2068957364 @default.
• W2035584793 cites W2069257334 @default.
• W2035584793 cites W2071107647 @default.
• W2035584793 cites W2073612561 @default.
• W2035584793 cites W2077813165 @default.
• W2035584793 cites W2082751682 @default.
• W2035584793 cites W2085093353 @default.
• W2035584793 cites W2091621798 @default.
• W2035584793 cites W2093979071 @default.
• W2035584793 cites W2095031817 @default.
• W2035584793 cites W2122442918 @default.
• W2035584793 cites W2148419227 @default.
• W2035584793 cites W2164358316 @default.
• W2035584793 cites W2167722613 @default.
• W2035584793 cites W2238363303 @default.
• W2035584793 cites W2332351571 @default.
• W2035584793 cites W4231472907 @default.
• W2035584793 doi "https://doi.org/10.1111/j.1471-4159.1992.tb08445.x" @default.
• W2035584793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1328520" @default.
• W2035584793 hasPublicationYear "1992" @default.
• W2035584793 type Work @default.
• W2035584793 sameAs 2035584793 @default.
• W2035584793 citedByCount "27" @default.
• W2035584793 countsByYear W20355847932013 @default.
• W2035584793 countsByYear W20355847932015 @default.
• W2035584793 crossrefType "journal-article" @default.
• W2035584793 hasAuthorship W2035584793A5023516295 @default.
• W2035584793 hasAuthorship W2035584793A5070033763 @default.
• W2035584793 hasAuthorship W2035584793A5071392053 @default.
• W2035584793 hasAuthorship W2035584793A5071694712 @default.
• W2035584793 hasAuthorship W2035584793A5082311017 @default.
• W2035584793 hasAuthorship W2035584793A5085484250 @default.
• W2035584793 hasConcept C11960822 @default.
• W2035584793 hasConcept C130316041 @default.
• W2035584793 hasConcept C148785051 @default.
• W2035584793 hasConcept C202751555 @default.
• W2035584793 hasConcept C26987225 @default.
• W2035584793 hasConcept C2778921374 @default.
• W2035584793 hasConcept C2908668639 @default.
• W2035584793 hasConcept C41625074 @default.
• W2035584793 hasConcept C50493954 @default.
• W2035584793 hasConcept C55493867 @default.
• W2035584793 hasConcept C86803240 @default.
• W2035584793 hasConcept C87325107 @default.
• W2035584793 hasConcept C95444343 @default.
• W2035584793 hasConcept C97029542 @default.
• W2035584793 hasConceptScore W2035584793C11960822 @default.
• W2035584793 hasConceptScore W2035584793C130316041 @default.
• W2035584793 hasConceptScore W2035584793C148785051 @default.
• W2035584793 hasConceptScore W2035584793C202751555 @default.
• W2035584793 hasConceptScore W2035584793C26987225 @default.
• W2035584793 hasConceptScore W2035584793C2778921374 @default.
• W2035584793 hasConceptScore W2035584793C2908668639 @default.
• W2035584793 hasConceptScore W2035584793C41625074 @default.
• W2035584793 hasConceptScore W2035584793C50493954 @default.
• W2035584793 hasConceptScore W2035584793C55493867 @default.
• W2035584793 hasConceptScore W2035584793C86803240 @default.
• W2035584793 hasConceptScore W2035584793C87325107 @default.
• W2035584793 hasConceptScore W2035584793C95444343 @default.
• W2035584793 hasConceptScore W2035584793C97029542 @default.
• W2035584793 hasLocation W20355847931 @default.
• W2035584793 hasLocation W20355847932 @default.
• W2035584793 hasOpenAccess W2035584793 @default.
• W2035584793 hasPrimaryLocation W20355847931 @default.
• W2035584793 hasRelatedWork W1481610803 @default.
• W2035584793 hasRelatedWork W1564969903 @default.
• W2035584793 hasRelatedWork W1985859189 @default.
• W2035584793 hasRelatedWork W2035584793 @default.

• next