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• W2035587046 abstract "Application of supercritical carbon dioxide in particle modification showed promising results due to less toxic solvent used and its relatively easy alteration on particle characteristic. Unfortunately, the use of this technology in herbal drugs or extracts is still limited. This research studied a new approach of herbal drugs processing technology. The micronization of Manilkara kauki L. Dubard's leaf extract (DLBS2347) using supercritical anti-solvent (SAS) was conducted with carbon dioxide as anti-solvent. Experiment results showed that type of solvents, pressure, temperature and carbon dioxide (CO2) mol fraction influenced its morphology and active compound concentration. Polar solvent such as dimethyl sulfoxide, methanol and ethanol produced sticky particle due to hygroscopic nature of simple carbohydrate that present in the product. Acetone precipitation of DLBS2347 has the highest active compound concentration. Lower pressure, temperature and CO2 mol fraction resulted small particle size (<1 μm) of DLBS2347. In addition, precipitation of active compound is mainly affected by pressure that correlated to extract impurities. Taken together, optimum condition for micronizing DLBS2347 using SAS with acetone solution was at 40 °C, 15 MPa and 0.95 mol fraction CO2." @default.
• W2035587046 created "2016-06-24" @default.
• W2035587046 creator A5030634729 @default.
• W2035587046 creator A5041368940 @default.
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• W2035587046 date "2013-12-01" @default.
• W2035587046 modified "2023-09-26" @default.
• W2035587046 title "Supercritical anti-solvent (SAS) micronization of Manilkara kauki bioactive fraction (DLBS2347)" @default.
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• W2035587046 doi "https://doi.org/10.1016/j.jcou.2013.09.001" @default.
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