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• W2035590596 abstract "Recent advances in proteomic techniques have resulted in an ever-increasing need to produce antibodies. Here, to address this problem, a technically simple approach of targeting the extreme C-termini of proteins with antibodies (CTAbs) was investigated in proteins secreted by the human pathogen Streptococcus pyogenes. Target proteins were identified by a conventional proteomic approach and CTAbs produced against synthetic five amino acid peptides representing the C-terminus of each target protein. In every case where protein secretion was demonstrated (n = 20), CTAbs were successfully produced and bound specifically to the target protein (100% success rate). The apparent specificity was consistent with the structural heterogeneity of the C-termini of S. pyogenes proteins. The global specificity of CTAb binding was defined using a combinatorial library of synthetic peptides representing structural variants of the original synthetic immunogen. This is a systematic and comprehensive approach for the development of antibodies with defined specificity that can be used in a range of applications." @default.
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• W2035590596 date "2007-05-01" @default.
• W2035590596 modified "2023-10-16" @default.
• W2035590596 title "C-Terminal antibodies (CTAbs): A simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity" @default.
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• W2035590596 doi "https://doi.org/10.1002/pmic.200600916" @default.
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