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- W2035594510 abstract "Tetrahydropyridazino-1,4-oxazinoisoquinoline derivatives with multidrug resistance (MDR) modulating activity were designed and synthesized. A key step for cyclization of 1,4-oxazine ring was developed using K 2 CO 3 and CH 3 CN in one-pot. Among prepared compounds, 2-(4-fluorobenzyl)-9,10-dimethoxy-12-methyl-6,7,11b,12-tetrahydropyridazino[4,5,5,6][1,4]oxazine-[3,4,-a]isoquinolin-1(2H)-one (lf) exhibited significant MDR reversing activity and low toxicity, which might be as potential MDR agent." @default.
- W2035594510 created "2016-06-24" @default.
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- W2035594510 date "2004-05-25" @default.
- W2035594510 modified "2023-10-12" @default.
- W2035594510 title "Synthetic Studies on Isoquinoline Derivatives with Multidrug Resistance (MDR) Modulating Activity." @default.
- W2035594510 cites W2950255883 @default.
- W2035594510 doi "https://doi.org/10.1002/chin.200421144" @default.
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