FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035604852> ?p ?o ?g. }

• W2035604852 endingPage "e101669" @default.
• W2035604852 startingPage "e101669" @default.
• W2035604852 abstract "Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the rectum which progressively extents. Its etiology remains unknown and the number of treatments available is limited. Studies of UC patients have identified an unbalanced endoplasmic reticulum (ER) stress in the non-inflamed colonic mucosa. Animal models with impaired ER stress are sensitive to intestinal inflammation, suggesting that an unbalanced ER stress could cause inflammation. However, there are no ER stress-regulating strategies proposed in the management of UC partly because of the lack of relevant preclinical model mimicking the disease. Here we generated the IL10/Nox1dKO mouse model which combines immune dysfunction (IL-10 deficiency) and abnormal epithelium (NADPH oxidase 1 (Nox1) deficiency) and spontaneously develops a UC-like phenotype with similar complications (colorectal cancer) than UC. Our data identified an unanticipated combined role of IL10 and Nox1 in the fine-tuning of ER stress responses in goblet cells. As in humans, the ER stress was unbalanced in mice with decreased eIF2α phosphorylation preceding inflammation. In IL10/Nox1dKO mice, salubrinal preserved eIF2α phosphorylation through inhibition of the regulatory subunit of the protein phosphatase 1 PP1R15A/GADD34 and prevented colitis. Thus, this new experimental model highlighted the central role of epithelial ER stress abnormalities in the development of colitis and defined the defective eIF2α pathway as a key pathophysiological target for UC. Therefore, specific regulators able to restore the defective eIF2α pathway could lead to the molecular remission needed to treat UC." @default.
• W2035604852 created "2016-06-24" @default.
• W2035604852 creator A5004703756 @default.
• W2035604852 creator A5005694972 @default.
• W2035604852 creator A5007191725 @default.
• W2035604852 creator A5010941913 @default.
• W2035604852 creator A5016241725 @default.
• W2035604852 creator A5019014483 @default.
• W2035604852 creator A5022296580 @default.
• W2035604852 creator A5022849571 @default.
• W2035604852 creator A5024904855 @default.
• W2035604852 creator A5028692465 @default.
• W2035604852 creator A5038154608 @default.
• W2035604852 creator A5046621175 @default.
• W2035604852 creator A5055053218 @default.
• W2035604852 creator A5058935731 @default.
• W2035604852 creator A5065188138 @default.
• W2035604852 creator A5070441072 @default.
• W2035604852 creator A5071588452 @default.
• W2035604852 creator A5075080951 @default.
• W2035604852 creator A5075464337 @default.
• W2035604852 creator A5075754745 @default.
• W2035604852 date "2014-07-09" @default.
• W2035604852 modified "2023-10-18" @default.
• W2035604852 title "Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice" @default.
• W2035604852 cites W1880023855 @default.
• W2035604852 cites W1892259311 @default.
• W2035604852 cites W1964510528 @default.
• W2035604852 cites W1976821584 @default.
• W2035604852 cites W1979299861 @default.
• W2035604852 cites W1981933987 @default.
• W2035604852 cites W1983571964 @default.
• W2035604852 cites W1987650422 @default.
• W2035604852 cites W1990978338 @default.
• W2035604852 cites W2000079184 @default.
• W2035604852 cites W2001712980 @default.
• W2035604852 cites W2008717984 @default.
• W2035604852 cites W2009035135 @default.
• W2035604852 cites W2020098501 @default.
• W2035604852 cites W2024766244 @default.
• W2035604852 cites W2031558979 @default.
• W2035604852 cites W2036500213 @default.
• W2035604852 cites W2037861078 @default.
• W2035604852 cites W2045549203 @default.
• W2035604852 cites W2056808649 @default.
• W2035604852 cites W2064656822 @default.
• W2035604852 cites W2073364986 @default.
• W2035604852 cites W2075094921 @default.
• W2035604852 cites W2080875750 @default.
• W2035604852 cites W2084429962 @default.
• W2035604852 cites W2089198803 @default.
• W2035604852 cites W2092541414 @default.
• W2035604852 cites W2099662390 @default.
• W2035604852 cites W2106779017 @default.
• W2035604852 cites W2116552560 @default.
• W2035604852 cites W2140267261 @default.
• W2035604852 cites W2140487984 @default.
• W2035604852 cites W2146314181 @default.
• W2035604852 cites W2146883005 @default.
• W2035604852 cites W2152736066 @default.
• W2035604852 cites W2163911998 @default.
• W2035604852 cites W4245737710 @default.
• W2035604852 doi "https://doi.org/10.1371/journal.pone.0101669" @default.
• W2035604852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4090121" @default.
• W2035604852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25014110" @default.
• W2035604852 hasPublicationYear "2014" @default.
• W2035604852 type Work @default.
• W2035604852 sameAs 2035604852 @default.
• W2035604852 citedByCount "41" @default.
• W2035604852 countsByYear W20356048522015 @default.
• W2035604852 countsByYear W20356048522016 @default.
• W2035604852 countsByYear W20356048522018 @default.
• W2035604852 countsByYear W20356048522019 @default.
• W2035604852 countsByYear W20356048522020 @default.
• W2035604852 countsByYear W20356048522021 @default.
• W2035604852 countsByYear W20356048522022 @default.
• W2035604852 countsByYear W20356048522023 @default.
• W2035604852 crossrefType "journal-article" @default.
• W2035604852 hasAuthorship W2035604852A5004703756 @default.
• W2035604852 hasAuthorship W2035604852A5005694972 @default.
• W2035604852 hasAuthorship W2035604852A5007191725 @default.
• W2035604852 hasAuthorship W2035604852A5010941913 @default.
• W2035604852 hasAuthorship W2035604852A5016241725 @default.
• W2035604852 hasAuthorship W2035604852A5019014483 @default.
• W2035604852 hasAuthorship W2035604852A5022296580 @default.
• W2035604852 hasAuthorship W2035604852A5022849571 @default.
• W2035604852 hasAuthorship W2035604852A5024904855 @default.
• W2035604852 hasAuthorship W2035604852A5028692465 @default.
• W2035604852 hasAuthorship W2035604852A5038154608 @default.
• W2035604852 hasAuthorship W2035604852A5046621175 @default.
• W2035604852 hasAuthorship W2035604852A5055053218 @default.
• W2035604852 hasAuthorship W2035604852A5058935731 @default.
• W2035604852 hasAuthorship W2035604852A5065188138 @default.
• W2035604852 hasAuthorship W2035604852A5070441072 @default.
• W2035604852 hasAuthorship W2035604852A5071588452 @default.
• W2035604852 hasAuthorship W2035604852A5075080951 @default.
• W2035604852 hasAuthorship W2035604852A5075464337 @default.
• W2035604852 hasAuthorship W2035604852A5075754745 @default.

• next