FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035608099> ?p ?o ?g. }

• W2035608099 endingPage "2633" @default.
• W2035608099 startingPage "2627" @default.
• W2035608099 abstract "Abstract Tumorigenesis is associated with enhanced cellular glucose uptake and increased metabolism. Because the p53 tumor suppressor is mutated in a large number of cancers, we evaluated whether p53 regulates expression of the GLUT1 and GLUT4 glucose transporter genes. Transient cotransfection of osteosarcoma-derived SaOS-2 cells, rhabdomyosarcoma-derived RD cells, and C2C12 myotubes with GLUT1-P-Luc or GLUT4-P-Luc promoter-reporter constructs and wild-type p53 expression vectors dose dependently decreased both GLUT1 and GLUT4 promoter activity to approximately 50% of their basal levels. PG13-Luc activity, which was used as a positive control for functional p53 expression, was increased up to ∼250-fold by coexpression of wild-type p53. The inhibitory effect of wild-type p53 was greatly reduced or abolished when cells were transfected with p53 with mutations in amino acids 143, 248, or 273. A region spanning −66/+163 bp of the GLUT4 promoter was both necessary and sufficient to mediate the inhibitory effects of p53. Furthermore, in vitro translated p53 protein was found to bind directly to two sequences in that region. p53-DNA binding was completely abolished by excess unlabeled probe but not by nonspecific DNA and was super-shifted by the addition of an anti-p53 antibody. Taken together, our data strongly suggest that wild-type p53 represses GLUT1 and GLUT4 gene transcription in a tissue-specific manner. Mutations within the DNA-binding domain of p53, which are usually associated with malignancy, were found to impair the repressive effect of p53 on transcriptional activity of the GLUT1 and GLUT4 gene promoters, thereby resulting in increased glucose metabolism and cell energy supply. This, in turn, would be predicted to facilitate tumor growth." @default.
• W2035608099 created "2016-06-24" @default.
• W2035608099 creator A5022181301 @default.
• W2035608099 creator A5036643076 @default.
• W2035608099 creator A5059289109 @default.
• W2035608099 date "2004-04-01" @default.
• W2035608099 modified "2023-10-16" @default.
• W2035608099 title "The Tumor Suppressor p53 Down-Regulates Glucose Transporters <b> <i>GLUT1</i> </b> and <b> <i>GLUT4</i> </b> Gene Expression" @default.
• W2035608099 cites W1513126834 @default.
• W2035608099 cites W1650797637 @default.
• W2035608099 cites W1674633125 @default.
• W2035608099 cites W1771632460 @default.
• W2035608099 cites W1965363596 @default.
• W2035608099 cites W1966099909 @default.
• W2035608099 cites W1974355172 @default.
• W2035608099 cites W1983587113 @default.
• W2035608099 cites W2006072603 @default.
• W2035608099 cites W2008307864 @default.
• W2035608099 cites W2008394600 @default.
• W2035608099 cites W2009458932 @default.
• W2035608099 cites W2010488171 @default.
• W2035608099 cites W2018241615 @default.
• W2035608099 cites W2018364757 @default.
• W2035608099 cites W2020592369 @default.
• W2035608099 cites W2024969833 @default.
• W2035608099 cites W2042721662 @default.
• W2035608099 cites W2043550216 @default.
• W2035608099 cites W2058659363 @default.
• W2035608099 cites W2060616628 @default.
• W2035608099 cites W2064689428 @default.
• W2035608099 cites W2068484236 @default.
• W2035608099 cites W2074222004 @default.
• W2035608099 cites W2076059928 @default.
• W2035608099 cites W2085020132 @default.
• W2035608099 cites W2085126858 @default.
• W2035608099 cites W2093969743 @default.
• W2035608099 cites W2117350062 @default.
• W2035608099 cites W2121220886 @default.
• W2035608099 cites W2121673811 @default.
• W2035608099 cites W2123732728 @default.
• W2035608099 cites W2131045322 @default.
• W2035608099 cites W2144693486 @default.
• W2035608099 cites W2148958834 @default.
• W2035608099 cites W2176176727 @default.
• W2035608099 cites W2255703111 @default.
• W2035608099 cites W2334988436 @default.
• W2035608099 doi "https://doi.org/10.1158/0008-5472.can-03-0846" @default.
• W2035608099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15059920" @default.
• W2035608099 hasPublicationYear "2004" @default.
• W2035608099 type Work @default.
• W2035608099 sameAs 2035608099 @default.
• W2035608099 citedByCount "596" @default.
• W2035608099 countsByYear W20356080992012 @default.
• W2035608099 countsByYear W20356080992013 @default.
• W2035608099 countsByYear W20356080992014 @default.
• W2035608099 countsByYear W20356080992015 @default.
• W2035608099 countsByYear W20356080992016 @default.
• W2035608099 countsByYear W20356080992017 @default.
• W2035608099 countsByYear W20356080992018 @default.
• W2035608099 countsByYear W20356080992019 @default.
• W2035608099 countsByYear W20356080992020 @default.
• W2035608099 countsByYear W20356080992021 @default.
• W2035608099 countsByYear W20356080992022 @default.
• W2035608099 countsByYear W20356080992023 @default.
• W2035608099 crossrefType "journal-article" @default.
• W2035608099 hasAuthorship W2035608099A5022181301 @default.
• W2035608099 hasAuthorship W2035608099A5036643076 @default.
• W2035608099 hasAuthorship W2035608099A5059289109 @default.
• W2035608099 hasConcept C101762097 @default.
• W2035608099 hasConcept C104317684 @default.
• W2035608099 hasConcept C134018914 @default.
• W2035608099 hasConcept C143065580 @default.
• W2035608099 hasConcept C150194340 @default.
• W2035608099 hasConcept C153911025 @default.
• W2035608099 hasConcept C161573976 @default.
• W2035608099 hasConcept C207583985 @default.
• W2035608099 hasConcept C2776188179 @default.
• W2035608099 hasConcept C2777866211 @default.
• W2035608099 hasConcept C2777952866 @default.
• W2035608099 hasConcept C2779306644 @default.
• W2035608099 hasConcept C2908666080 @default.
• W2035608099 hasConcept C502942594 @default.
• W2035608099 hasConcept C55493867 @default.
• W2035608099 hasConcept C555283112 @default.
• W2035608099 hasConcept C86803240 @default.
• W2035608099 hasConceptScore W2035608099C101762097 @default.
• W2035608099 hasConceptScore W2035608099C104317684 @default.
• W2035608099 hasConceptScore W2035608099C134018914 @default.
• W2035608099 hasConceptScore W2035608099C143065580 @default.
• W2035608099 hasConceptScore W2035608099C150194340 @default.
• W2035608099 hasConceptScore W2035608099C153911025 @default.
• W2035608099 hasConceptScore W2035608099C161573976 @default.
• W2035608099 hasConceptScore W2035608099C207583985 @default.
• W2035608099 hasConceptScore W2035608099C2776188179 @default.
• W2035608099 hasConceptScore W2035608099C2777866211 @default.
• W2035608099 hasConceptScore W2035608099C2777952866 @default.
• W2035608099 hasConceptScore W2035608099C2779306644 @default.
• W2035608099 hasConceptScore W2035608099C2908666080 @default.

• next