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• W2035615280 abstract "Background: Ovarian hyperstimulation syndrome (OHSS) is one of the known risks of infertility treatment. A debate has evolved regarding the best method for preventing OHSS. No consensus has been reached. Several options have been proposed, including IVF cycle cancellation, intravenous albumin administration, withholding gonadotropin administration (i.e., coasting), and cryopreserving all embryos for future transfer. If a patient becomes pregnant in a stimulated cycle, endogenous hCG can influence the duration and severity of OHSS. Objective: This study was designed to examine the pregnancy outcomes of patients at high risk of OHSS who underwent elective cryopreservation of all embryos with subsequent transfer in a nonstimulated cycle, thereby eliminating the risk of pregnancy in the stimulated cycle. Materials and Methods: In this retrospective chart review, data were extracted from the medical records of patients at a private IVF clinic who underwent elective cryopreservation of all embryos secondary to risk of OHSS with subsequent transfer in an unstimulated cycle. The charts from January 2000 to October 2007 were reviewed. The control group was selected by reviewing the charts of patients who had a peak estradiol level greater than 4,000 pg/ml who underwent transfer of fresh embryos in the stimulated cycle. These charts from January 2004 to August 2006 were reviewed. Data were analyzed using the independent t test and chi-squared test. Results: The study included 41 patients in the fresh transfer group and 33 patients in the cryopreservation group. There were significant differences seen in the number of oocytes retrieved and subsequently the number of oocytes cryopreserved. The clinical pregnancy rates per transfer and per patient, as well as the live birth rates per transfer and per patient are shown in the table and do not show any statistically significant differences.Tabled 1Fresh TransferElective cryopreservationP valueNo. of patients4133Age32.0 ± 4.230.5 ± 3.1NSPeak estradiol level5245.1 ± 946.95475.2 ± 3007.5NSNo. of oocytes retrieved22.7 ± 6.735.1 ± 12.4<.001No. of oocytes cryopreserved5.5 ± 5.814.0 ± 7.5<.001Clinical pregnancy rate per transfer36.07%41.38%.552Clinical pregnancy rate per patient48.78%66.67%.465Livebirth rate per transfer31.15%39.66%.332Livebirth rate per patient43.90%66.67%.052 Open table in a new tab Conclusions: Patients who had all embryos electively cryopreserved and then transfered in a nonstimulated cycle had slightly higher, although not statistically significant, pregnancy and live birth rates as those who underwent a fresh transfer. Given the excellent pregnancy rates, elective cryopreservation of all embryos is a viable option to prevent pregnancy in the stimulated cycle and thereby potentially decrease the duration and/or severity of ovarian hyperstimulation syndrome." @default.
• W2035615280 created "2016-06-24" @default.
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• W2035615280 date "2008-04-01" @default.
• W2035615280 modified "2023-09-26" @default.
• W2035615280 title "Outcomes of Elective Cryopreservation of All Embryos in Women at High Risk of Developing Ovarian Hyperstimulation Syndrome (OHSS)" @default.
• W2035615280 doi "https://doi.org/10.1016/j.fertnstert.2008.02.061" @default.
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