Matches in SemOpenAlex for { <https://semopenalex.org/work/W20356429> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W20356429 endingPage "34" @default.
- W20356429 startingPage "627" @default.
- W20356429 abstract "Several matrix metalloproteinase (MMP) polymorphisms favouring the development of lung fibrosis after pulmonary tuberculosis (TB) have been described.To investigate the association of MMP-1, MMP-9 and MMP-12 polymorphisms with the development of fibrosis in pulmonary TB.We studied 49 normal subjects and 98 TB patients. We analysed the association between MMP polymorphisms and clinical indices of lung fibrosis by serial chest radiography for 1 year after completion of treatment.The frequency of the MMP-1(-1607G) polymorphism was significantly higher in TB patients with moderate to advanced pulmonary fibrosis than in those with minimal to mild fibrosis. Having at least one -1607G MMP-1 polymorphism increased the risk of moderate and advanced fibrosis respectively by 5.04 (95%CI 1.25-20.30) and 9.87 (95%CI 2.39-40.88) fold. There was no association of MMP-9(-1562T) and MMP-12(Asn357Ser) polymorphisms with lung fibrosis. The production of MMP-1 from monocytes stimulated by interleukin-1 beta was increased in subjects with the 1G allele genotype compared to the 2G/2G genotype.Patients with MMP-1(-1607G) polymorphism are more vulnerable to more extensive lung fibrosis 1 year after anti-tuberculosis treatment. This may be related to increased MMP-1 activity, leading to enhanced destruction of the matrix with subsequent fibrosis." @default.
- W20356429 created "2016-06-24" @default.
- W20356429 creator A5002440301 @default.
- W20356429 creator A5011617733 @default.
- W20356429 creator A5013069037 @default.
- W20356429 creator A5039824713 @default.
- W20356429 creator A5040749080 @default.
- W20356429 creator A5049201518 @default.
- W20356429 creator A5066715763 @default.
- W20356429 creator A5075275067 @default.
- W20356429 creator A5085996676 @default.
- W20356429 date "2010-05-01" @default.
- W20356429 modified "2023-10-13" @default.
- W20356429 title "MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan." @default.
- W20356429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20392358" @default.
- W20356429 hasPublicationYear "2010" @default.
- W20356429 type Work @default.
- W20356429 sameAs 20356429 @default.
- W20356429 citedByCount "15" @default.
- W20356429 countsByYear W203564292013 @default.
- W20356429 countsByYear W203564292014 @default.
- W20356429 countsByYear W203564292015 @default.
- W20356429 countsByYear W203564292016 @default.
- W20356429 countsByYear W203564292018 @default.
- W20356429 countsByYear W203564292019 @default.
- W20356429 countsByYear W203564292021 @default.
- W20356429 countsByYear W203564292022 @default.
- W20356429 crossrefType "journal-article" @default.
- W20356429 hasAuthorship W20356429A5002440301 @default.
- W20356429 hasAuthorship W20356429A5011617733 @default.
- W20356429 hasAuthorship W20356429A5013069037 @default.
- W20356429 hasAuthorship W20356429A5039824713 @default.
- W20356429 hasAuthorship W20356429A5040749080 @default.
- W20356429 hasAuthorship W20356429A5049201518 @default.
- W20356429 hasAuthorship W20356429A5066715763 @default.
- W20356429 hasAuthorship W20356429A5075275067 @default.
- W20356429 hasAuthorship W20356429A5085996676 @default.
- W20356429 hasConcept C126322002 @default.
- W20356429 hasConcept C142724271 @default.
- W20356429 hasConcept C2776178081 @default.
- W20356429 hasConcept C2777714996 @default.
- W20356429 hasConcept C2781069245 @default.
- W20356429 hasConcept C2908628106 @default.
- W20356429 hasConcept C29456083 @default.
- W20356429 hasConcept C2983914783 @default.
- W20356429 hasConcept C71924100 @default.
- W20356429 hasConceptScore W20356429C126322002 @default.
- W20356429 hasConceptScore W20356429C142724271 @default.
- W20356429 hasConceptScore W20356429C2776178081 @default.
- W20356429 hasConceptScore W20356429C2777714996 @default.
- W20356429 hasConceptScore W20356429C2781069245 @default.
- W20356429 hasConceptScore W20356429C2908628106 @default.
- W20356429 hasConceptScore W20356429C29456083 @default.
- W20356429 hasConceptScore W20356429C2983914783 @default.
- W20356429 hasConceptScore W20356429C71924100 @default.
- W20356429 hasIssue "5" @default.
- W20356429 hasLocation W203564291 @default.
- W20356429 hasOpenAccess W20356429 @default.
- W20356429 hasPrimaryLocation W203564291 @default.
- W20356429 hasRelatedWork W1570090732 @default.
- W20356429 hasRelatedWork W1783051299 @default.
- W20356429 hasRelatedWork W1856528204 @default.
- W20356429 hasRelatedWork W1857752585 @default.
- W20356429 hasRelatedWork W1987825791 @default.
- W20356429 hasRelatedWork W1989249240 @default.
- W20356429 hasRelatedWork W2009074395 @default.
- W20356429 hasRelatedWork W2011815185 @default.
- W20356429 hasRelatedWork W2015060528 @default.
- W20356429 hasRelatedWork W2071723955 @default.
- W20356429 hasRelatedWork W2087621739 @default.
- W20356429 hasRelatedWork W2105675616 @default.
- W20356429 hasRelatedWork W2109543073 @default.
- W20356429 hasRelatedWork W2122744065 @default.
- W20356429 hasRelatedWork W2126451498 @default.
- W20356429 hasRelatedWork W2143377299 @default.
- W20356429 hasRelatedWork W2156608020 @default.
- W20356429 hasRelatedWork W2158953087 @default.
- W20356429 hasRelatedWork W2168456456 @default.
- W20356429 hasRelatedWork W2400050383 @default.
- W20356429 hasVolume "14" @default.
- W20356429 isParatext "false" @default.
- W20356429 isRetracted "false" @default.
- W20356429 magId "20356429" @default.
- W20356429 workType "article" @default.