FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035649587> ?p ?o ?g. }

• W2035649587 endingPage "117" @default.
• W2035649587 startingPage "111" @default.
• W2035649587 abstract "Low-molecular-weight heparin has the potential for the treatment of ulcerative colitis, and targeted drug delivery to the colon is important for topical treatment of this disease, so low-molecular-weight heparin oral colon-specific delivery capsule was prepared, and the in vitro and in vivo drug release behavior was investigated. The macroscopical and histological scoring systems, wet colon mass index and myeloperoxidase activity were assessed to evaluate the efficacy of the capsule after administered orally to experimental colitis mice. Serum levels, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and a link factor of blood coagulation and inflammation factor Xa (FXa) were assayed by enzyme-linked immunosorbent assay. The expression of Musashi-1 (as an intestinal stem cell marker) in the colons was assessed by immunohistochemical analysis. The in vitro and in vivo drug release studies clearly indicated that the specific coated capsules were capable of protecting low-molecular-weight heparin from releasing in stomach and small intestine, while specifically delivering at colon. The oral colon-specific delivery capsule of low-molecular-weight heparin could attenuate macroscopic and histological features of colitis. The results showed that low-molecular-weight heparin oral colon-specific delivery capsule significantly decreased the serum levels of TNF-α, IL-6 as well as FXa, while increased the expression of Musashi-1 in colon compared with acetic acid-induced ulcerative colitis model group. The results showed that low-molecular-weight heparin oral colon-specific delivery capsule had the potential for treatment of inflammatory bowel disease." @default.
• W2035649587 created "2016-06-24" @default.
• W2035649587 creator A5020786545 @default.
• W2035649587 creator A5025878951 @default.
• W2035649587 creator A5034321132 @default.
• W2035649587 creator A5072569858 @default.
• W2035649587 date "2011-03-01" @default.
• W2035649587 modified "2023-09-27" @default.
• W2035649587 title "Efficacy of oral colon-specific delivery capsule of low-molecular-weight heparin on ulcerative colitis" @default.
• W2035649587 cites W13621163 @default.
• W2035649587 cites W1600381110 @default.
• W2035649587 cites W1975006580 @default.
• W2035649587 cites W1976467447 @default.
• W2035649587 cites W1983344050 @default.
• W2035649587 cites W1990557296 @default.
• W2035649587 cites W1994416600 @default.
• W2035649587 cites W1998519641 @default.
• W2035649587 cites W2003384516 @default.
• W2035649587 cites W2003571504 @default.
• W2035649587 cites W2007822205 @default.
• W2035649587 cites W2014912947 @default.
• W2035649587 cites W2037423916 @default.
• W2035649587 cites W2040890002 @default.
• W2035649587 cites W2045972295 @default.
• W2035649587 cites W2050068056 @default.
• W2035649587 cites W2053077754 @default.
• W2035649587 cites W2054491191 @default.
• W2035649587 cites W2056936400 @default.
• W2035649587 cites W2064596993 @default.
• W2035649587 cites W2069417660 @default.
• W2035649587 cites W2071137515 @default.
• W2035649587 cites W2079909796 @default.
• W2035649587 cites W2083561402 @default.
• W2035649587 cites W2087890839 @default.
• W2035649587 cites W2088981039 @default.
• W2035649587 cites W2102270036 @default.
• W2035649587 cites W2118178438 @default.
• W2035649587 cites W2124787187 @default.
• W2035649587 cites W2147378461 @default.
• W2035649587 cites W2153358709 @default.
• W2035649587 cites W2153933922 @default.
• W2035649587 cites W2156953890 @default.
• W2035649587 cites W2186530519 @default.
• W2035649587 cites W300797676 @default.
• W2035649587 cites W4292198229 @default.
• W2035649587 doi "https://doi.org/10.1016/j.biopha.2010.12.013" @default.
• W2035649587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21227626" @default.
• W2035649587 hasPublicationYear "2011" @default.
• W2035649587 type Work @default.
• W2035649587 sameAs 2035649587 @default.
• W2035649587 citedByCount "19" @default.
• W2035649587 countsByYear W20356495872012 @default.
• W2035649587 countsByYear W20356495872013 @default.
• W2035649587 countsByYear W20356495872014 @default.
• W2035649587 countsByYear W20356495872015 @default.
• W2035649587 countsByYear W20356495872016 @default.
• W2035649587 countsByYear W20356495872017 @default.
• W2035649587 countsByYear W20356495872018 @default.
• W2035649587 countsByYear W20356495872020 @default.
• W2035649587 countsByYear W20356495872021 @default.
• W2035649587 crossrefType "journal-article" @default.
• W2035649587 hasAuthorship W2035649587A5020786545 @default.
• W2035649587 hasAuthorship W2035649587A5025878951 @default.
• W2035649587 hasAuthorship W2035649587A5034321132 @default.
• W2035649587 hasAuthorship W2035649587A5072569858 @default.
• W2035649587 hasConcept C126322002 @default.
• W2035649587 hasConcept C150903083 @default.
• W2035649587 hasConcept C203014093 @default.
• W2035649587 hasConcept C207001950 @default.
• W2035649587 hasConcept C2775862500 @default.
• W2035649587 hasConcept C2776884760 @default.
• W2035649587 hasConcept C2777557582 @default.
• W2035649587 hasConcept C2778260677 @default.
• W2035649587 hasConcept C2778778583 @default.
• W2035649587 hasConcept C2779134260 @default.
• W2035649587 hasConcept C2780479503 @default.
• W2035649587 hasConcept C59822182 @default.
• W2035649587 hasConcept C71924100 @default.
• W2035649587 hasConcept C86803240 @default.
• W2035649587 hasConcept C90924648 @default.
• W2035649587 hasConcept C98274493 @default.
• W2035649587 hasConceptScore W2035649587C126322002 @default.
• W2035649587 hasConceptScore W2035649587C150903083 @default.
• W2035649587 hasConceptScore W2035649587C203014093 @default.
• W2035649587 hasConceptScore W2035649587C207001950 @default.
• W2035649587 hasConceptScore W2035649587C2775862500 @default.
• W2035649587 hasConceptScore W2035649587C2776884760 @default.
• W2035649587 hasConceptScore W2035649587C2777557582 @default.
• W2035649587 hasConceptScore W2035649587C2778260677 @default.
• W2035649587 hasConceptScore W2035649587C2778778583 @default.
• W2035649587 hasConceptScore W2035649587C2779134260 @default.
• W2035649587 hasConceptScore W2035649587C2780479503 @default.
• W2035649587 hasConceptScore W2035649587C59822182 @default.
• W2035649587 hasConceptScore W2035649587C71924100 @default.
• W2035649587 hasConceptScore W2035649587C86803240 @default.
• W2035649587 hasConceptScore W2035649587C90924648 @default.
• W2035649587 hasConceptScore W2035649587C98274493 @default.
• W2035649587 hasIssue "2" @default.

• next