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- W2035659618 abstract "Mechanochemical technology enables solvent-free micronized solid dispersions and efficient molecular host–guest inclusion complexes to be formed in matrices which contain cyclodextrins (CDs). This type of complexation has been studied using α-, β- and γ-cyclodextrin with the dual aims of improving overall solubility and enhancing the bioavailability of common steroid compounds, such as cholic acids and β-sitosterols or lowering cholesterol content in products of animal origin. Several parameters have been studied and optimized: CD/compound molar ratio (1:1, 1:2, 2:1 and 3:1) in function of the cavity sizes of the three different CDs, milling time (from 5 to 40 min) and rotation speed (from 100 to 300 rpm). DSC (differential scanning calorimetry) analyses have revealed that inclusion complexes were efficiently formed after 40 min milling (200 rpm) for β-CD/cholesterol and β-CD/ugrsodeoxycholic acid (encapsulation efficiency 96% and 77% respectively). Besides steroid encapsulation/vehiculation, the mechanochemical technique may pave the way for new ideas in solventless steroid extraction from vegetal matrices with CDs." @default.
- W2035659618 created "2016-06-24" @default.
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- W2035659618 date "2015-06-01" @default.
- W2035659618 modified "2023-10-04" @default.
- W2035659618 title "Efficient mechanochemical complexation of various steroid compounds with α-, β- and γ-cyclodextrin" @default.
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- W2035659618 doi "https://doi.org/10.1016/j.steroids.2015.02.016" @default.
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